CAJ | 학술논문

目的：探讨不同核苷酸切除修复交叉互补基因组1（ERCC1）N118N基因型与接受铂类药物化疗的上皮性卵巢癌患者化疗敏感性的关系。方法采用Taqman探针基因分型技术检测92例上皮性卵巢癌患者外周血ERCC1 N118N单核苷酸多态性。所有患者均接受以铂类药物为主的方案化疗（紫杉醇+顺铂或环磷酰胺+顺铂），比较不同基因型与患者化疗敏感性的关系。结果92例患者中第118位密码子基因型的分布是CT+TT型为42.4％，CC型57.6％；CT+TT型者对铂类化疗药物的敏感性显著高于CC型者（P=0.029）。结论 ERCC1第118位密码子的基因多态性与卵巢癌患者铂类药物化疗敏感性有关。
목적：탐토불동핵감산절제수복교차호보기인조1（ERCC1）N118N기인형여접수박류약물화료적상피성란소암환자화료민감성적관계。방법채용Taqman탐침기인분형기술검측92례상피성란소암환자외주혈ERCC1 N118N단핵감산다태성。소유환자균접수이박류약물위주적방안화료（자삼순+순박혹배린선알+순박），비교불동기인형여환자화료민감성적관계。결과92례환자중제118위밀마자기인형적분포시CT+TT형위42.4％，CC형57.6％；CT+TT형자대박류화료약물적민감성현저고우CC형자（P=0.029）。결론 ERCC1제118위밀마자적기인다태성여란소암환자박류약물화료민감성유관。
Objective To investigate the association of ERCC1 N118 N gene polymorphism with chemotherapy sensi-tivity in epithelial ovarian cancer patients treated with platinum- based chemotherapy (taxol+ cisplatin, cyclophosphamide+cisplatin). Methods Ninety two patients with epithelial ovarian cancer treated with platinum- based chemotherapy were includ-ed in the study. Pre- treatment anticoagulated blood samples were col ected for extraction of genomic DNA. The TaqMan method was used to genotype single nucleotide polymorphisms (SNPs) in ERCC1 N118N gene. Results The genotype distribution at codon 118 was 57.6% with C/C and 42.4% with C/T+TT. Platinum- resistance was less frequently in patients with the C/T + T/T genotype (P=0.029). Conclusion ERCC1 N118 N gene polymorphism may be associated with chemotherapy sensitivity in ep-ithelial ovarian cancer patients treated with platinum- based chemotherapy.