中国性科学
中國性科學
중국성과학
THE CHINESE JOURNAL OF HUMAN SEXUALITY
2015年
5期
107-110
,共4页
罗永芳%冯玲%李莉%魏雄艳
囉永芳%馮玲%李莉%魏雄豔
라영방%풍령%리리%위웅염
阿司匹林%人绒毛膜促性腺激素%抗心磷脂抗体阳性早孕复发性流产%疗效%安全性
阿司匹林%人絨毛膜促性腺激素%抗心燐脂抗體暘性早孕複髮性流產%療效%安全性
아사필림%인융모막촉성선격소%항심린지항체양성조잉복발성유산%료효%안전성
Aspirin%Human chorionic gonadotropin%Recurrent miscarriage with positive anticar-diolipin antibody%Efficacy%Safety
目的：对阿司匹林联合激素类药物治疗抗心磷脂抗体阳性早孕复发性流产的疗效和安全性进行研究，证实该治疗方案的临床价值。方法：以我院2011年8月至2012年8月两年间治疗的抗心磷脂抗体阳性早孕复发性流产患者72例为研究对象，采用随机数字表法将其分为观察和对照组，每组36例。对照组采用人绒毛膜促性腺激素治疗；观察组在对照组治疗的基础上口服小剂量的阿司匹林和强的松。治疗后随访1年，对两组研究对象的孕娩情况及不良反应进行比较。结果：观察组研究对象足月分娩26例，占72.2％，流产3例，未孕7例；对照组足月分娩9例，占25％，流产18例，未孕9例。就足月分娩率进行组间比较，观察组高于对照组，且具有显著差异性（P ＜0.05）；观察组不良反应发生率为11.1％低于对照组13.8％的不良发应率，但不具有显著差异性（P ＞0.05）；观察组患者治疗依从性与对照组比较差异无明显的统计学意义（P ＞0.05）。结论：在绒毛膜促性腺激素治疗的基础上予以阿司匹林联合激素类药物在抗心磷脂抗体阳性早孕复发性流产治疗中疗效显著，安全性高，且不会降低患者治疗的依从性，具有重要的临床价值，适于推广使用。
目的：對阿司匹林聯閤激素類藥物治療抗心燐脂抗體暘性早孕複髮性流產的療效和安全性進行研究，證實該治療方案的臨床價值。方法：以我院2011年8月至2012年8月兩年間治療的抗心燐脂抗體暘性早孕複髮性流產患者72例為研究對象，採用隨機數字錶法將其分為觀察和對照組，每組36例。對照組採用人絨毛膜促性腺激素治療；觀察組在對照組治療的基礎上口服小劑量的阿司匹林和彊的鬆。治療後隨訪1年，對兩組研究對象的孕娩情況及不良反應進行比較。結果：觀察組研究對象足月分娩26例，佔72.2％，流產3例，未孕7例；對照組足月分娩9例，佔25％，流產18例，未孕9例。就足月分娩率進行組間比較，觀察組高于對照組，且具有顯著差異性（P ＜0.05）；觀察組不良反應髮生率為11.1％低于對照組13.8％的不良髮應率，但不具有顯著差異性（P ＞0.05）；觀察組患者治療依從性與對照組比較差異無明顯的統計學意義（P ＞0.05）。結論：在絨毛膜促性腺激素治療的基礎上予以阿司匹林聯閤激素類藥物在抗心燐脂抗體暘性早孕複髮性流產治療中療效顯著，安全性高，且不會降低患者治療的依從性，具有重要的臨床價值，適于推廣使用。
목적：대아사필림연합격소류약물치료항심린지항체양성조잉복발성유산적료효화안전성진행연구，증실해치료방안적림상개치。방법：이아원2011년8월지2012년8월량년간치료적항심린지항체양성조잉복발성유산환자72례위연구대상，채용수궤수자표법장기분위관찰화대조조，매조36례。대조조채용인융모막촉성선격소치료；관찰조재대조조치료적기출상구복소제량적아사필림화강적송。치료후수방1년，대량조연구대상적잉면정황급불량반응진행비교。결과：관찰조연구대상족월분면26례，점72.2％，유산3례，미잉7례；대조조족월분면9례，점25％，유산18례，미잉9례。취족월분면솔진행조간비교，관찰조고우대조조，차구유현저차이성（P ＜0.05）；관찰조불량반응발생솔위11.1％저우대조조13.8％적불량발응솔，단불구유현저차이성（P ＞0.05）；관찰조환자치료의종성여대조조비교차이무명현적통계학의의（P ＞0.05）。결론：재융모막촉성선격소치료적기출상여이아사필림연합격소류약물재항심린지항체양성조잉복발성유산치료중료효현저，안전성고，차불회강저환자치료적의종성，구유중요적림상개치，괄우추엄사용。
Objectives:To study the efficacy and safety of aspirin combined hormone therapy in treating re-current miscarriage with positive anticardiolipin antibody.Methods:72 recurrent miscarriage patients with positive anti -cardiolipin antibodies in our hospital between August 2011 and August 2012 were selected and randomly di-vided into observation group and control group,each of 36 cases.Control group received human chorionic gonadotro-pin therapy,and observation group was treated with low -dose aspirin and prednisone on the basis of the control group.The childbirth situation and incidence of adverse reactions of the two groups were compared in the 1 -year follow -up.Results:In the observation group,26 cases had term delivery,accounting for 72.2%,3 cases of mis-carriage and 7 cases of non -pregnancy.In the control group,there were 9 cases (25%)of term delivery,18 cases of miscarriage and 9 cases of non -pregnancy.Difference in the full -term delivery rates between the two groups was significant (P <0.05).The incidence of adverse reaction in observed group was 11.1%,lower than the control group of 13.8%,but not with significant difference (P >0.05).Difference in the treatment compliance between the two groups was not statistically significant (P >0.05).Conclusion:Aspirin combined hormone human chorion-ic gonadotropin,is of significant treatment effect on recurrent miscarriage with positive anticardiolipin antibody, which is safe and has high treatment compliance,thusly worthy wide application.
