大家健康(下旬版)
大傢健康(下旬版)
대가건강(하순판)
FOR ALL HEALTH
2015年
5期
11-11,12
,共2页
李晟%蔡琳%张楠%张润岐
李晟%蔡琳%張楠%張潤岐
리성%채림%장남%장윤기
Fascin-1%大肠腺瘤%大肠癌%免疫组化
Fascin-1%大腸腺瘤%大腸癌%免疫組化
Fascin-1%대장선류%대장암%면역조화
Fascin-1%colorectal adenoma%colorectal carcinoma%IHC
目的:分析正常大肠黏膜、大肠腺瘤和大肠癌中Fascin-1的表达及其意义。方法:用免疫组化方法检测不同大肠组织中Fascin-1的表达情况,并结合大肠癌临床病理参数进行分析。结果:正常大肠粘膜中未检测到Fascin-1表达,大肠腺瘤、大肠癌中表达率分别为18.42%和60.47%;大肠癌中Fascin-1的表达和肿瘤侵犯浆膜、淋巴结转移、远处转移以及分期相关。结论:在大肠癌发生过程中,Fascin-1蛋白表达逐步增强,在大肠癌中显著高表达,并与大肠癌的浸润、转移密切相关。
目的:分析正常大腸黏膜、大腸腺瘤和大腸癌中Fascin-1的錶達及其意義。方法:用免疫組化方法檢測不同大腸組織中Fascin-1的錶達情況,併結閤大腸癌臨床病理參數進行分析。結果:正常大腸粘膜中未檢測到Fascin-1錶達,大腸腺瘤、大腸癌中錶達率分彆為18.42%和60.47%;大腸癌中Fascin-1的錶達和腫瘤侵犯漿膜、淋巴結轉移、遠處轉移以及分期相關。結論:在大腸癌髮生過程中,Fascin-1蛋白錶達逐步增彊,在大腸癌中顯著高錶達,併與大腸癌的浸潤、轉移密切相關。
목적:분석정상대장점막、대장선류화대장암중Fascin-1적표체급기의의。방법:용면역조화방법검측불동대장조직중Fascin-1적표체정황,병결합대장암림상병리삼수진행분석。결과:정상대장점막중미검측도Fascin-1표체,대장선류、대장암중표체솔분별위18.42%화60.47%;대장암중Fascin-1적표체화종류침범장막、림파결전이、원처전이이급분기상관。결론:재대장암발생과정중,Fascin-1단백표체축보증강,재대장암중현저고표체,병여대장암적침윤、전이밀절상관。
Objective:To observe expression of Fascin-1 in colorectal mucosa,colorectal adenoma and colorectal cancer. Methods:The expression of Fas-cin-1 in different colorectal tissues were detected by immunohistochemical method.Results:The expression rate of Fascin -1 was 0% in colorectal mucosa, 18.42% in colorectal adenoma and 60.47% in colorectal cancer;The expression of Fascin-1 in colorectal cancer correlated with serosa invasion,lymph node metastasis,distant metastasis and staging of tumor.Conclusion:The Fascin-1 expression gradually increased in colorectal carcinogenesis and significantly higher in colorectal cancer. It closely related with the invasion and metastasis.