CAJ | 학술논문

目的：建立基于药物体系的肉桂特征图谱质量表征关联分析方法，全面评价肉桂饮片质量。方法采用HPLC－PDA法建立肉桂饮片特征图谱，筛选7个特征峰并通过相对保留时间表征其质的关联性；同时测定6个主要有效指标性成分（原儿茶酸、表儿茶素、香豆素、肉桂醇、肉桂酸、肉桂醛）的含量并表征主要酚类成分和主要苯丙素类成分的含量，通过关联度等概念表征其量的关联性。结果以批号13为基准，基于质的表征模式及关联分析，肉桂饮片特征图谱中筛选的7个特征峰中有酚类成分2个、苯丙素类成分5个，15批肉桂饮片色谱图中均含有此7个特征峰。基于量的表征模式及关联分析，批号14有效指标性成分总体含量高于基准批号13，批号4、6、8、10含量与基准批号13关联性较高，综合评价得出批号14、13、4、6、8、10优良度居前。结论在定性的基础上进行定量表征，可全面评价肉桂饮片质量优次，为肉桂饮片资源筛选、药物原料质量控制及应用提供依据，同时为中药质量评价提供新的方法。
목적：건립기우약물체계적육계특정도보질량표정관련분석방법，전면평개육계음편질량。방법채용HPLC－PDA법건립육계음편특정도보，사선7개특정봉병통과상대보류시간표정기질적관련성；동시측정6개주요유효지표성성분（원인다산、표인다소、향두소、육계순、육계산、육계철）적함량병표정주요분류성분화주요분병소류성분적함량，통과관련도등개념표정기량적관련성。결과이비호13위기준，기우질적표정모식급관련분석，육계음편특정도보중사선적7개특정봉중유분류성분2개、분병소류성분5개，15비육계음편색보도중균함유차7개특정봉。기우량적표정모식급관련분석，비호14유효지표성성분총체함량고우기준비호13，비호4、6、8、10함량여기준비호13관련성교고，종합평개득출비호14、13、4、6、8、10우량도거전。결론재정성적기출상진행정량표정，가전면평개육계음편질량우차，위육계음편자원사선、약물원료질량공제급응용제공의거，동시위중약질량평개제공신적방법。
Objective To establish quality representation and correlation analysis method for analyzing the characteristic spectrum of Rougui ( Cinnamomum cassia Presl.) based on drug system, evaluating the quality of Rougui decocting pieces comprehensively.Methods HPLC-PDA method was adopted to establish the characteristic spectrum of Rougui decocting pieces, and seven characteristic peaks were screened.The qualitative relevance was presented with the relative retention time characterization. Simultaneously, six main effective index components ( protocatechuic acid, epicatechin, coumarin, cinnamic alcohol, cinnamic acid, and cinnamaldehyde) were measured, and characterization contents of the main phenols and the main phenylpropanoids were presented, whose quantitative relevance was represented with correlation analysis.Results Using batch 13 as reference standards, based on the qualitative representation model and correlation analysis, seven characteristic peaks of Rougui decocting pieces were detected to have two characteristic peaks of phenols and five characteristic peaks of phenylpropanoids;the seven characteristic peaks were found in 15 batches of Rougui decocting pieces chromatograms .Based on the quantitative representation model and correlation analysis, the overall amount of effective index components in batch 14 were higher than those in batch 13; the levels of components in batch 4, 6, 8, and 10 were highly related to batch 13.Comprehensive evaluation result showed that the quality of batch 14, 13, 4, 6, 8, and 10 were comparatively higher.Conclusion Quality representation was carried out on the basis of the qualitative characterization.This method could evaluate Rougui pieces’ quality comprehensively, provide a basis for the screening of resources, for con-trolling the quality of pharmaceutical raw materials, and for the related application, and also provide a new methodology for quality evaluation of Chinese materia medica.