国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2015年
3期
173-175
,共3页
糖尿病肾病%MiRNA-150%炎症%肾脏纤维化
糖尿病腎病%MiRNA-150%炎癥%腎髒纖維化
당뇨병신병%MiRNA-150%염증%신장섬유화
Diabetic nephropathy%MiRNA-150%Inflammation%Renal fibrosis
糖尿病肾病以肾间质纤维化和肾脏硬化为病理学特点,慢性低度炎性反应、氧化应激、新生血管形成、内皮功能紊乱等在糖尿病肾病的发生和发展中起重要作用.MiRNA-150参与多种炎性反应、调节炎性反应信号通路,在肾脏纤维化中表达升高,而且可以通过微泡促进新生血管形成,进而导致肾间质纤维化,肾脏硬化;其靶基因,如细胞因子信号转导抑制蛋白1 (SOCS1)、基质细胞衍生因子-1(SDF-1)/趋化因子受体4(CXCR4)等在糖尿病肾病中起保护作用.因此,miRNA-150可能通过影响其下游信号分子的表达在糖尿病肾病的发生、发展中起重要作用.
糖尿病腎病以腎間質纖維化和腎髒硬化為病理學特點,慢性低度炎性反應、氧化應激、新生血管形成、內皮功能紊亂等在糖尿病腎病的髮生和髮展中起重要作用.MiRNA-150參與多種炎性反應、調節炎性反應信號通路,在腎髒纖維化中錶達升高,而且可以通過微泡促進新生血管形成,進而導緻腎間質纖維化,腎髒硬化;其靶基因,如細胞因子信號轉導抑製蛋白1 (SOCS1)、基質細胞衍生因子-1(SDF-1)/趨化因子受體4(CXCR4)等在糖尿病腎病中起保護作用.因此,miRNA-150可能通過影響其下遊信號分子的錶達在糖尿病腎病的髮生、髮展中起重要作用.
당뇨병신병이신간질섬유화화신장경화위병이학특점,만성저도염성반응、양화응격、신생혈관형성、내피공능문란등재당뇨병신병적발생화발전중기중요작용.MiRNA-150삼여다충염성반응、조절염성반응신호통로,재신장섬유화중표체승고,이차가이통과미포촉진신생혈관형성,진이도치신간질섬유화,신장경화;기파기인,여세포인자신호전도억제단백1 (SOCS1)、기질세포연생인자-1(SDF-1)/추화인자수체4(CXCR4)등재당뇨병신병중기보호작용.인차,miRNA-150가능통과영향기하유신호분자적표체재당뇨병신병적발생、발전중기중요작용.
The pathologic characteristics of diabetic nephropathy are renal interstitial fibrosis and renal sclerosis.Chronic low-grade inflammation,oxidative stress,angiogenesis and endothelial dysfunction play important roles in the occurrence and development of diabetic nephropathy.MiRNA-150,overexpressed in renal fibrosis,participates in a variety of inflammatory response and inflammatory signaling pathways.Through microvesicels,miRNA-150 can promote angiogenesis and then result in renal interstitial fibrosis and nephrosclerosis.Its target genes are protective in diabetic nephropathy,such as suppressor of cytokine signaling1 (SOCS1),stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor4 (CXCR4).Therefore,miRNA-150 may play a key role in the occurrence and development of diabetic nephropathy by modulating its downstream signaling molecules.
