CAJ | 학술논문

随着肥胖成为流行性疾病,肥胖相关性肾病(ORG)的发生率明显升高.ORG的发生与胰岛素抵抗、高瘦素血症、脂代谢异常、肾素-血管紧张素-醛固酮系统(RAAS)激活和氧化应激等因素密切相关.生活方式改变、减轻体重、使用改善胰岛素抵抗药物、抑制RAAS活性药物以及选择性抗炎药物等有助于延缓ORG进展.
수착비반성위류행성질병,비반상관성신병(ORG)적발생솔명현승고.ORG적발생여이도소저항、고수소혈증、지대사이상、신소-혈관긴장소-철고동계통(RAAS)격활화양화응격등인소밀절상관.생활방식개변、감경체중、사용개선이도소저항약물、억제RAAS활성약물이급선택성항염약물등유조우연완ORG진전.
With the epidemic of obesity,the incidence of obesity-related glomerulopathy (ORG) has increased significantly.The pathogenetic mechanisms of ORG include:insulin resistance,hyperleptinemia,lipid metabolic disorders,activation of renin angiotensin aldosterone system(RAAS),oxidative stress and so on.Lifestyle modification,weight loss,drug therapy of insulin resistance,RAAS blockade and selective antiinflammatory drugs may be beneficial to ameliorate the progression of ORG.