CAJ | 학술논문

Glypican-4是一种新的脂肪细胞因子,其在皮下和内脏脂肪组织中差异表达,并与体重指数、腰臀比密切相关.Glypican-4通过直接与胰岛素受体结合,发挥类似胰岛素的作用,促进葡萄糖的摄取和前脂肪细胞的分化.在肥胖和糖尿病等具有胰岛素抵抗的患者中,glypican-4可通过代偿性分泌增加,维持机体血糖水平正常.Glypican-4是第一个被发现能直接与胰岛素受体结合,发挥增强胰岛素信号转导作用的脂肪细胞因子.研究其在胰岛素信号转导方面的功能将可能为肥胖和糖尿病的诊治带来新的契机.
Glypican-4시일충신적지방세포인자,기재피하화내장지방조직중차이표체,병여체중지수、요둔비밀절상관.Glypican-4통과직접여이도소수체결합,발휘유사이도소적작용,촉진포도당적섭취화전지방세포적분화.재비반화당뇨병등구유이도소저항적환자중,glypican-4가통과대상성분비증가,유지궤체혈당수평정상.Glypican-4시제일개피발현능직접여이도소수체결합,발휘증강이도소신호전도작용적지방세포인자.연구기재이도소신호전도방면적공능장가능위비반화당뇨병적진치대래신적계궤.
Glypican-4 serving as a novel adipokine is differentially expressed in visceral and subcutaneous adipose tissue,and its expression is also highly correlated with body mass index and waist-to-hip ratio.Glypican-4 interacts with insulin receptor,exerts the similar role as insulin and promotes glucose uptake and adipocyte differentiation.The increase of the compensatory glypican-4 secretion is observed in obese and diabetic patients with insulin resistance,which can help to maintain normal blood glucose.Glypican-4 is the first adipose-derived insulin sensitizer which acts directly on the insulin receptor to enhance insulin signaling.Further study of the function of glypican-4 in insulin signaling may bring new opportunity for the diagnosis and treatment of obesity and diabetes.