CAJ | 학술논문

代谢综合征是心血管疾病的多种代谢危险因素在个体内集结的状态,主要包括肥胖、糖尿病或糖调节受损、血脂紊乱以及高血压.近来研究发现,代谢综合征的发病与机体慢性炎性反应状态相关.类胰蛋白酶是肥大细胞中含量最丰富的颗粒蛋白,也是一种重要的炎性介质,它可通过促进炎性反应细胞的聚集、细胞凋亡、新生血管形成、基质蛋白重塑等多种机制参与代谢综合征的发生与发展.
대사종합정시심혈관질병적다충대사위험인소재개체내집결적상태,주요포괄비반、당뇨병혹당조절수손、혈지문란이급고혈압.근래연구발현,대사종합정적발병여궤체만성염성반응상태상관.류이단백매시비대세포중함량최봉부적과립단백,야시일충중요적염성개질,타가통과촉진염성반응세포적취집、세포조망、신생혈관형성、기질단백중소등다충궤제삼여대사종합정적발생여발전.
Metabolic syndrome is the clustering of cardiovascular risk factors in body,including obesity,diabetes or impaired glucose tolerance,dyslipidemia,and hypertension.Recent studies suggest that the onset of metabolic syndrome is associated with the state of chronic inflammation.Tryptase is the most abundant grain protein contents in mast cells,and also the important inflammatory mediator,it can participate in the occurrence and development of metabolic syndrome by inducing inflammatory cell recruitment,cell apoptosis,angiogenesis,and matrix protein remodeling.