国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2015年
3期
208-210
,共3页
胰岛素瘤%胰腺内分泌肿瘤%多发性内分泌腺瘤病1型%胰高血糖素样肽-1受体%乙醇消融法
胰島素瘤%胰腺內分泌腫瘤%多髮性內分泌腺瘤病1型%胰高血糖素樣肽-1受體%乙醇消融法
이도소류%이선내분비종류%다발성내분비선류병1형%이고혈당소양태-1수체%을순소융법
Insulinoma%Pancreatic endocrine tumors%Multiple endocrine neoplasia type 1%Glucagon-like peptide 1 receptor%Ethanol ablation
既往研究认为大多数胰岛素瘤的发生与多发性内分泌腺瘤病1型基因及其产物menin蛋白有关,而近年来相继发现新的基因如YY1 (Yin Yang1)也参与其中.由于大多数瘤体直径＜1 cm,临床上很难进行定位诊断.68镓(68Ga)标记胰高血糖素样肽-1受体激动剂的正电子发射计算机断层显像(PET-CT)检查有助于提高阳性检出率.目前外科手术仍是胰岛素瘤的首选治疗方法,对于高龄或者不适合手术的患者,超声内镜介导的乙醇消融法可作为治疗选择.
既往研究認為大多數胰島素瘤的髮生與多髮性內分泌腺瘤病1型基因及其產物menin蛋白有關,而近年來相繼髮現新的基因如YY1 (Yin Yang1)也參與其中.由于大多數瘤體直徑＜1 cm,臨床上很難進行定位診斷.68鎵(68Ga)標記胰高血糖素樣肽-1受體激動劑的正電子髮射計算機斷層顯像(PET-CT)檢查有助于提高暘性檢齣率.目前外科手術仍是胰島素瘤的首選治療方法,對于高齡或者不適閤手術的患者,超聲內鏡介導的乙醇消融法可作為治療選擇.
기왕연구인위대다수이도소류적발생여다발성내분비선류병1형기인급기산물menin단백유관,이근년래상계발현신적기인여YY1 (Yin Yang1)야삼여기중.유우대다수류체직경＜1 cm,림상상흔난진행정위진단.68가(68Ga)표기이고혈당소양태-1수체격동제적정전자발사계산궤단층현상(PET-CT)검사유조우제고양성검출솔.목전외과수술잉시이도소류적수선치료방법,대우고령혹자불괄합수술적환자,초성내경개도적을순소융법가작위치료선택.
Multiple endocrine neoplasia 1 (MEN1) gene and its coding protein-menin were firstly found associated with insulinoma,whereas many new genes have been discovered to be associated with insulinoma,such as YY 1 (Yin Yang1).Since the diameters of most insulinomas are smaller than 1 cm,it is too difficult to locate the tumor with conventional methods.Positron emission tomography (PET) scan with glucagon-like peptide 1 receptor agonists labeled by 68Gallium(68Ga)has been shown efficient in improving the tumor detecting rate.Surgical resection is still a preferred treatment for insulinoma.However Eus-guided ethanol ablation may be an alternative therapy for some patients,especially for aged people.
