CAJ | 학술논문

目的探讨胰腺神经内分泌癌的临床病理特点和影响患者预后的相关因素.方法回顾性分析复旦大学附属中山医院2000年4月至2013年8月收治的21例胰腺神经内分泌癌患者的临床病理和随访资料,对可能影响患者预后的相关因素进行统计学分析.结果单因素分析显示,年龄、临床分期、肿瘤大小、肿瘤分化程度及有无淋巴结转移对患者的存活率影响差异均有统计学意义(均P＜0.05).多因素分析(Cox回归)显示,年龄(P =0.019)是影响患者预后的独立危险因素,年龄＜60岁者,预后较好.结论胰腺神经内分泌癌患者多为无功能性,大多数无特殊临床表现,易发生远处转移,年龄是影响患者预后的独立危险因素.
목적 탐토이선신경내분비암적림상병리특점화영향환자예후적상관인소.방법 회고성분석복단대학부속중산의원2000년4월지2013년8월수치적21례이선신경내분비암환자적림상병리화수방자료,대가능영향환자예후적상관인소진행통계학분석.결과 단인소분석현시,년령、림상분기、종류대소、종류분화정도급유무림파결전이대환자적존활솔영향차이균유통계학의의(균P＜0.05).다인소분석(Cox회귀)현시,년령(P =0.019)시영향환자예후적독립위험인소,년령＜60세자,예후교호.결론 이선신경내분비암환자다위무공능성,대다수무특수림상표현,역발생원처전이,년령시영향환자예후적독립위험인소.
Objective To analyze the clinicopathological characteristics and the related factors influencing the prognosis of pancreatic neuroendocrine carcinoma.Methods The clinicpathological and follow-up data of 21 patients with pancreatic neuroendocrine carcinoma admitted between April 2000 and August 2013 in Zhongshan Hospital of Fudan University were analyzed retrospectively.The influence facts on patients' prognosis were analyzed statistically.Results Univariate analysis showed that age,stage,tumor size,degree of tumor differentiation and lymph node metastasis were factors separately influenced patients' survival.Multivariate analysis (Cox regression) revealed that age (P =0.019) was the only independent factor affecting the prognosis.Conclusions Patients with pancreatic neuroendocrine carcinoma were mostly non-functional and presented no specific clinical features.Tumors tended to metastasize and the prognosis was poor.Age was the independent factor affecting the prognosis.