CAJ | 학술논문

目的：比较不同剂量埃索美拉唑预防消化性溃疡并出血内镜止血后再出血的效果。方法108例消化性溃疡并出血患者经肾上腺素粘膜下注射联合电凝或止血夹治疗成功止血后,随机分成2组。大剂量组给予埃索美拉唑80 mg静推+8 mg/h输注,维持72 h；标准剂量组给予埃索美拉唑80 mg静推+40 mg静推, q12 h,维持72 h。两组患者随后均给予埃索美拉唑20 mg,1次/d,维持治疗27 d。结果大剂量组72 h、7 d、30 d再出血率分别为5．6%、9．3%、9．3%,与标准剂量组(7．4%、9．3%、11．1%)比较差异无统计学意义( P >0．05)。两组患者住院时间、外科手术率、死亡率比较差异无统计学意义(P>0．05)。结论不同剂量埃索美拉唑预防高危消化性溃疡并出血内镜止血后再出血的效果相当。
목적：비교불동제량애색미랍서예방소화성궤양병출혈내경지혈후재출혈적효과。방법108례소화성궤양병출혈환자경신상선소점막하주사연합전응혹지혈협치료성공지혈후,수궤분성2조。대제량조급여애색미랍서80 mg정추+8 mg/h수주,유지72 h；표준제량조급여애색미랍서80 mg정추+40 mg정추, q12 h,유지72 h。량조환자수후균급여애색미랍서20 mg,1차/d,유지치료27 d。결과대제량조72 h、7 d、30 d재출혈솔분별위5．6%、9．3%、9．3%,여표준제량조(7．4%、9．3%、11．1%)비교차이무통계학의의( P >0．05)。량조환자주원시간、외과수술솔、사망솔비교차이무통계학의의(P>0．05)。결론불동제량애색미랍서예방고위소화성궤양병출혈내경지혈후재출혈적효과상당。
Objective To compare the preventive effect of different doses of esomeprazole on hemorrhage af-ter endoscopic haemostasis. Methods A total of 108 patients with bleeding ulcers undergoing endoscopic treatment with epinephrine injection and heater probe thermocoagulation or clip were randomized to receive a high-dose regimen (80 mg bolus,followed by esomeprazole 8 mg/h infusion,n=54) or a standard-dose regimen ( esomeprazole 40 mg bolus q12h,n=54). After 72 h,all patients were given 20 mg esomeprazole daily orally for 27 d. Results The rates of recurrent bleeding in 72 h,7 d and 30 d separately were 5. 6%,9. 3%,9. 3% in high dose group,and 7. 4%,9. 3%, 11. 1% in standard dose group(P>0. 05). There was no significant difference in hospital stay time,the rate of surgical interventions and mortality between the two groups. Conclusion Different doses of esomeprazole show similar effect on the prevention of recurrent haemorrhage after endoscopic haemostasis in high-risk bleeding peptic ulcers.