CAJ | 학술논문

纳米药物载体有延长药物作用时间、增加疗效、降低毒副作用、缓控释给药等优点。而生物可降解高分子材料因其良好的生物利用度、载药能力和控释能力以及较低的毒性而被广泛用于纳米药物。本文综述了聚乳酸-羟基乙酸共聚物( PLGA)、聚乳酸( PLA)、聚己内酯( PCL)高分子化合物制备纳米粒的合成和载药方法及应用。
납미약물재체유연장약물작용시간、증가료효、강저독부작용、완공석급약등우점。이생물가강해고분자재료인기량호적생물이용도、재약능력화공석능력이급교저적독성이피엄범용우납미약물。본문종술료취유산-간기을산공취물( PLGA)、취유산( PLA)、취기내지( PCL)고분자화합물제비납미립적합성화재약방법급응용。
Nanoparticulate drug delivery systems have advantages over conventional drug delivery systems due to their long drug duration,improvement of therapeutic value,less toxic properties,and control release. Biodegradable nanoparticles have been used frequently as drug delivery vehicles because of their good bioavailability,drug-loading a-bility and controlled-release ability and small toxicity. In this paper,the development of preparation methods of biode-gradable polymeric nanoparticles including PLGA,PLA,PCL of drug and their clinical application are reviewed.