CAJ | 학술논문

目的：评估缬沙坦或替米沙坦与氨氯地平联合治疗原发性高血压的临床疗效及效价分析。方法选择2014年9-11月我院确诊的原发性高血压患者200例,随机分为2组,缬沙坦组(缬沙坦80 mg,氨氯地平5 mg,1次/d)和替米沙坦组(替米沙坦40 mg,氨氯地平5 mg,1次/d),比较两组的临床疗效、不良反应及效价比。结果治疗8周后,缬沙坦组总有效率为94%,替米沙坦组总有效率为95%,两组总有效率比较差异无统计学意义(P>0．05)。治疗期间,两组患者不良反应发生率差异无统计学意义(P>0．05)。替米沙坦组药物经济学价值高于缬沙坦组。结论缬沙坦或替米沙坦联合氨氯地平在高血压治疗中的降压效果满意,患者耐受性好,不良反应发生率低。替米沙坦联合氨氯地平治疗更能节约用药成本。
목적：평고힐사탄혹체미사탄여안록지평연합치료원발성고혈압적림상료효급효개분석。방법선택2014년9-11월아원학진적원발성고혈압환자200례,수궤분위2조,힐사탄조(힐사탄80 mg,안록지평5 mg,1차/d)화체미사탄조(체미사탄40 mg,안록지평5 mg,1차/d),비교량조적림상료효、불량반응급효개비。결과치료8주후,힐사탄조총유효솔위94%,체미사탄조총유효솔위95%,량조총유효솔비교차이무통계학의의(P>0．05)。치료기간,량조환자불량반응발생솔차이무통계학의의(P>0．05)。체미사탄조약물경제학개치고우힐사탄조。결론힐사탄혹체미사탄연합안록지평재고혈압치료중적강압효과만의,환자내수성호,불량반응발생솔저。체미사탄연합안록지평치료경능절약용약성본。
Objective To evaluate the clinical effect and cost-effectiveness of valsartan or telmisartan com-bined with amlodipine in the treatment of hypertension. Methods 200 patients with primary hypertension in our hospi-tal from September to November in 2014 were randomly divided into two group,valsartan group was given valsartan 80 mg combined with amlodipine,5 mg,once daily,telmisartan group was given telmisartan 40 mg combined with amlo-dipine,5 mg, once daily. The clinical effect, adverse reactions and cost-effectiveness of the two groups were com-pared. Results After 8 weeks′treatment,the total efficacy rate of valsartan group was 94%,while it was 95% in telm-isartan group, there was no significant difference in total efficacy rate and adverse reaction rate between the two groups. In terms of cost-effectiveness, telmisartan group was better than valsartan group. Conclusion Valsartan or telmisartan combined with amlodipine in the treatment of hypertension is perfect with low adverse reaction rates, and the cost of telmisartan combined with amlodipine treatment is lower.