CAJ | 학술논문

目的：采用FACT-H&N量表评价核黄素磷酸钠对喉癌放疗患者生存质量的影响。方法选取我院肿瘤科首次接受放射治疗的喉癌患者72例，随机分为观察组和对照组，每组36例。观察组自放疗开始每日应用核黄素磷酸钠20 mg静脉输液，直至放疗结束；对照组单纯放疗，不使用核黄素磷酸钠。观察两组患者放疗后放射性口咽黏膜炎的发生率和摄食量，分别于放疗前( D1)和放疗后( D2)采用FACT-H&N量表作为评测工具，评价放疗前后两组患者生存质量。结果观察组放射性口咽黏膜炎的发生率低于对照组，两组比较差异有统计学意义(P<0．05)；观察组患者摄食量与对照组比较差异有统计学意义(P<0．05)；生存质量方面，观察组在身体状况、社会家庭、情感及功能共性模块评分均高于对照组，在头颈部模块的附加条目领域得分低于对照组，两组比较差异有统计学意义(P<0．05)。结论核黄素磷酸钠可降低放射性口咽黏膜炎发生率，改善喉癌放疗患者摄食量下降，提高喉癌放疗患者生存质量，值得临床推广。
목적：채용FACT-H&N량표평개핵황소린산납대후암방료환자생존질량적영향。방법선취아원종류과수차접수방사치료적후암환자72례，수궤분위관찰조화대조조，매조36례。관찰조자방료개시매일응용핵황소린산납20 mg정맥수액，직지방료결속；대조조단순방료，불사용핵황소린산납。관찰량조환자방료후방사성구인점막염적발생솔화섭식량，분별우방료전( D1)화방료후( D2)채용FACT-H&N량표작위평측공구，평개방료전후량조환자생존질량。결과관찰조방사성구인점막염적발생솔저우대조조，량조비교차이유통계학의의(P<0．05)；관찰조환자섭식량여대조조비교차이유통계학의의(P<0．05)；생존질량방면，관찰조재신체상황、사회가정、정감급공능공성모괴평분균고우대조조，재두경부모괴적부가조목영역득분저우대조조，량조비교차이유통계학의의(P<0．05)。결론핵황소린산납가강저방사성구인점막염발생솔，개선후암방료환자섭식량하강，제고후암방료환자생존질량，치득림상추엄。
Objective Using FACT-H&N scale to evaluate the effect of riboflavin sodium phosphate on the quality of life of patients with laryngeal carcinoma who received radiotherapy. Methods Seventy-two patients with la-ryngeal carcinoma who underwent radiotherapy for the first time were randomly divided into observation group and con-trol group. Patients in observation group (n=36) accepted daily application of riboflavin sodium phosphate 20 mg in-travenous infusion throughout the course of radiotherapy. Patients in control group only received radiotherapy. The oc-currence of oropharyngeal mucositis and food intake after radiotherapy were assessed by FACT-HN scale to evaluate the quality of life of patients before (D1) and after (D2) radiotherapy. Results The incidence of oral mucositis in obser-vation group was lower than that of control group,there was significant difference (P<0. 05);There was significant difference in the food intake status between the two groups (P<0. 05);For the quality of life,the scores of physical condition,social and family,the general module emotional and functional in patients of observation group were higher than those of control group (P<0. 05),and the scores of the head and neck module additional entry field of observa-tion group were lower than those than that of control group (P<0. 05),the difference was significant. Conclusion Riboflavin sodium phosphate can reduce the incidence of radioactive oral mucositis,improve the decrease of food intake in laryngeal carcinoma patients who underwent radiotherapy and improve the quality of life,it is worthy of clinical pro-motion.