CAJ | 학술논문

骨髓来源的抑制细胞（ myeloid?derived suppressor cells， MDSCs）是具有免疫抑制功能的细胞群，主要通过抑制T细胞的功能，抑制机体的免疫反应，促使疾病的发生发展。随着MDSCs为靶点的抗肿瘤治疗作用凸显，人们对MDSCs的关注也日渐升温，并取得了一定的研究成果。本文就MDSCs免疫抑制的作用机制及其在动物实验、临床研究中潜在的相关治疗靶点进行综述，旨在为恶性肿瘤的免疫治疗提供新思路。
골수래원적억제세포（ myeloid?derived suppressor cells， MDSCs）시구유면역억제공능적세포군，주요통과억제T세포적공능，억제궤체적면역반응，촉사질병적발생발전。수착MDSCs위파점적항종류치료작용철현，인문대MDSCs적관주야일점승온，병취득료일정적연구성과。본문취MDSCs면역억제적작용궤제급기재동물실험、림상연구중잠재적상관치료파점진행종술，지재위악성종류적면역치료제공신사로。
Myeloid?derived suppressor cells( MDSCs) is a crowd of cells, which can suppress the immune response, mainly by inhibiting T cells' function, as a result, contributing to the genesis and development of disease. With the increasing importance of MD?SCs as targets for treatment of cancer, more and more people have given considerable attention to it, and have achieved certain results. In this paper we reviewed the MDSCs' immunosuppressive mechanism, and the role of MDSCs as potential targets in animal experi?ments, as well as in clinical researches, aiming at offering new insights into the treatment of malignant tumor.