CAJ | 학술논문

目的：探讨微波辐射导致的雄小鼠生殖功能障碍的中医证候。方法：应用以方测证法研究，即通过循证医学确定男性不育症临床证候并遴选代表方剂，应用这些方剂治疗微波辐射性生殖功能障碍雄小鼠，通过精子总活率、快速向前精子率、畸形率及睾丸病理改变判断疗效，依据疗效判断证候。结果：无论是基准辐射，还是加功辐射、加时辐射，金匮肾气丸对其全部精液参数都有显著疗效，同时，金匮肾气丸还可以改善微波辐射损伤小鼠睾丸组织病变；其他方剂仅对部分精液参数有疗效，而且对辐射损伤睾丸的病理变化无改善。结论：微波辐射性雄小鼠生殖功能障碍的证候是肾阳虚证。
목적：탐토미파복사도치적웅소서생식공능장애적중의증후。방법：응용이방측증법연구，즉통과순증의학학정남성불육증림상증후병린선대표방제，응용저사방제치료미파복사성생식공능장애웅소서，통과정자총활솔、쾌속향전정자솔、기형솔급고환병리개변판단료효，의거료효판단증후。결과：무론시기준복사，환시가공복사、가시복사，금궤신기환대기전부정액삼수도유현저료효，동시，금궤신기환환가이개선미파복사손상소서고환조직병변；기타방제부대부분정액삼수유료효，이차대복사손상고환적병리변화무개선。결론：미파복사성웅소서생식공능장애적증후시신양허증。
Objectives:To study the TCM syndrome of male mice reproductive dysfunction caused by mi-crowave radiation.Methods:Applying the method speculating the syndrome with prescription,that is,determining clinical syndromes of male infertility by evidence -based medicine and selecting the representative prescriptions, applying these prescriptions to treat male mice’s reproductive dysfunction caused by microwave radiation and jud-ging syndrome according to the curative effect through sperm PR +NP,PR and abnormality rate and testicular patho-logical change.Results:Golden Coffer Kidney Qi Pill had remarkable curative effect on all seminal parameters of benchmark radiation group or more power and more time radiation groups Meanwhile,Golden Coffer Kidney Qi Pill could also improve mice testicular tissue lesions damaged by the microwave radiation.Other prescriptions had cura-tive effect on part of the seminal parameters and no improvement on the pathological changes of the testes damaged by radiation.Conclusion:The syndrome of male mice reproductive dysfunction caused by microwave radiation is kidney yang vacuity syndrome.