CAJ | 학술논문

目的：探究分析激光术后结合干扰素局部封闭治疗尖锐湿疣患者的临床疗效。方法：选择2011年3月至2013年7月来我院诊治的80例尖锐湿疣患者，按照随机数字表法分为实验组和对照组，每组患者40例。对照组患者只采取 CO2激光治疗，实验组患者在对照组治疗基础之上结合利分能干扰素治疗。观察两组患者治疗前后 IL －2、IL －10以及 IL －4等炎症因子水平的变化；比较两组患者的临床治疗效果。结果：治疗前，实验组患者 IL －2、IL －10以及 IL －4的水平与对照组患者比较无显著性差异（P ＞0.05）；经过治疗，实验组患者的 IL －2水平显著升高，IL －10以及 IL －4的水平显著降低，均较对照组患者变化大，具有统计学意义（P ＜0.05），且实验组患者的三项指标的治疗前后的差值均较对照组患者大，具有显著性差异（P ＜0.05）；经过治疗，实验组患者的总有效率为97.5％，较对照组患者高，差异性比较明显（P ＜0.05）。结论：激光术后结合干扰素局部封闭治疗尖锐湿疣患者，能够显著改变患者外周血清炎症因子的水平，明显提高临床疗效，是一种值得推广的治疗方法。
목적：탐구분석격광술후결합간우소국부봉폐치료첨예습우환자적림상료효。방법：선택2011년3월지2013년7월래아원진치적80례첨예습우환자，안조수궤수자표법분위실험조화대조조，매조환자40례。대조조환자지채취 CO2격광치료，실험조환자재대조조치료기출지상결합리분능간우소치료。관찰량조환자치료전후 IL －2、IL －10이급 IL －4등염증인자수평적변화；비교량조환자적림상치료효과。결과：치료전，실험조환자 IL －2、IL －10이급 IL －4적수평여대조조환자비교무현저성차이（P ＞0.05）；경과치료，실험조환자적 IL －2수평현저승고，IL －10이급 IL －4적수평현저강저，균교대조조환자변화대，구유통계학의의（P ＜0.05），차실험조환자적삼항지표적치료전후적차치균교대조조환자대，구유현저성차이（P ＜0.05）；경과치료，실험조환자적총유효솔위97.5％，교대조조환자고，차이성비교명현（P ＜0.05）。결론：격광술후결합간우소국부봉폐치료첨예습우환자，능구현저개변환자외주혈청염증인자적수평，명현제고림상료효，시일충치득추엄적치료방법。
Objectives:To explore the clinical efficacy of laser surgery combined with partial closure of in-terferon in treating patients with genital warts.Methods:80 patients with genital warts in our hospital from March 2011 to July 2013 were selected and randomly divided into experimental group and control group,each group of 40 patients.Patients in the control group received only carbon dioxide laser treatment,while patients in the experimen-tal group received combined therapy of interferon therapy.Changes in the IL -2,IL -10 and IL -4 levels of in-flammatory cytokines of the two groups’patients before and after were observed;and the clinical outcomes were compared.Results:Before treatment,difference in IL -2,IL -10 and IL -4 between the two groups was not sig-nificant (P >0.05);after treatment,IL -2 levels in the experimental group significantly increased,and the level of IL -10 and IL -4 was significantly reduced,with statistical significant difference between the two groups (P <0.05);changes in the three indicators of patients in the experimental group was significantly larger than that in the control group (P <0.05);after treatment,the total effective rate of the experimental group were 97.5%,higher than that of the control group,with significant difference (P <0.05).Conclusion:Laser surgery combined with partial closure of interferon therapy can significantly change the level of inflammatory cytokines in peripheral blood of patients,significantly improve the clinical efficacy,which is worthy of promotion.