CAJ | 학술논문

目的：探讨咪喹莫特对尖锐湿疣皮损朗格汉斯细胞的影响。方法：以2011年6月到2013年5月我院收治的60例尖锐湿疣患者为研究对象，通过免疫组化染色及定量分析，计算治疗前后朗格汉斯细胞染色强度平均灰度值，统计咪喹莫特治疗尖锐湿疣的疗效。结果：采用咪喹莫特治疗尖锐湿疣2周，总有效率为65.4％，治疗4周，总有效率为73.1％，治疗8周，总有效率为82.7％，治疗16周，总有效率为86.5％。治疗前，朗格汉斯细胞染色强度平均灰度值为（67.39±17.61），治疗后，朗格汉斯细胞染色强度平均灰度值为（107.20±24.33），差异具有统计学意义（P ＜0.05）。结论：咪喹莫特可能通过促进朗格汉斯细胞恢复来治疗尖锐湿疣。
목적：탐토미규막특대첨예습우피손랑격한사세포적영향。방법：이2011년6월도2013년5월아원수치적60례첨예습우환자위연구대상，통과면역조화염색급정량분석，계산치료전후랑격한사세포염색강도평균회도치，통계미규막특치료첨예습우적료효。결과：채용미규막특치료첨예습우2주，총유효솔위65.4％，치료4주，총유효솔위73.1％，치료8주，총유효솔위82.7％，치료16주，총유효솔위86.5％。치료전，랑격한사세포염색강도평균회도치위（67.39±17.61），치료후，랑격한사세포염색강도평균회도치위（107.20±24.33），차이구유통계학의의（P ＜0.05）。결론：미규막특가능통과촉진랑격한사세포회복래치료첨예습우。
Objectives:To investigate the effects of imiquimod on Lange Hans cells in the skin lesions of patients with genital warts.Methods:60 patients with genital warts in our hospital from 2011 June to 2013 May were selected as the research objects.Through the analysis of immunohistochemical staining and quantitative calcu-lation before and after treatment of Lange Hans cell mean staining gray intensity value,efficacy of imiquimod in the treatment of genital warts patients were calculated.Results:After two weeks of imiquimod treatment of genital warts,the total effective rate was 65.4%;four weeks after treatment,the total effective rate was 73.1%;eight weeks after treatment,the total effective rate was 82.7%;16 weeks after treatment,the total effective rate was 86. 5%.The average gray value of Lange Hans cells staining intensity (67.39 ±17.61)before treatment was different from that after treatment (107.20 ±24.33),with statistically significant difference (P <0.05).Conclusion:Imiquimod,through promoting the recovery of Lange Hans cells,to treat genital warts.