CAJ | 학술논문

目的：对比观察不同剂量丙种球蛋白（IVIG）治疗新生儿 AVO 溶血病的临床疗效。方法对97例出生后1 d、2 d、3~5 d 入院的诊断为 AVO 溶血病的新生儿进行临床回顾性分组研究，其中33例患儿（A 组）给予大剂量IVIG（1 g/ kg），33例患儿（V 组）给予小剂量 IVIG（0.4 g/ kg），31例患者（C 组）未使用 IVIG，作为临床对照组。观察各组出生后1 d、2 d、3~5 d 入院的新生儿经治疗后血清总胆红素（TVIL）的变化。结果在1 d、2 d、3~5 d 入院的患儿，血清 TVIL 水平逐渐升高；经过24 h、48 h 的治疗，A 组 TVIL 水平均明显低于 V、C 组（ P <0.05）。结论早期、大剂量IVIG 能够有效降低新生儿 AVO 溶血病患儿血清 TVIL 水平，减少黄疸及其后遗症的发生。
목적：대비관찰불동제량병충구단백（IVIG）치료신생인 AVO 용혈병적림상료효。방법대97례출생후1 d、2 d、3~5 d 입원적진단위 AVO 용혈병적신생인진행림상회고성분조연구，기중33례환인（A 조）급여대제량IVIG（1 g/ kg），33례환인（V 조）급여소제량 IVIG（0.4 g/ kg），31례환자（C 조）미사용 IVIG，작위림상대조조。관찰각조출생후1 d、2 d、3~5 d 입원적신생인경치료후혈청총담홍소（TVIL）적변화。결과재1 d、2 d、3~5 d 입원적환인，혈청 TVIL 수평축점승고；경과24 h、48 h 적치료，A 조 TVIL 수평균명현저우 V、C 조（ P <0.05）。결론조기、대제량IVIG 능구유효강저신생인 AVO 용혈병환인혈청 TVIL 수평，감소황달급기후유증적발생。
Objective To observe and contrast the clinical curative effect of neonatal AVO hemolytic disease with different dose of gamma globulin(IVIG). Methods The cases of 97 patients with neonatal AVO hemolytic disease after birth 1 d,2 d,3 ~ 5 d in our hospital were studied retrospectively. 33 cases patients children(group A)were given a high dose of IVIG(1 g/ kg). 33 patients children(group V)were given low dose of IVIG(0. 4 g/ kg). 31 patients(group C)without IVIG treatment were used as controls. The change of serum total bilirubin(TVIL)of each group who hospitalized and treated after 1 d,2 d,3 ~ 5 d birth. Results After 24 hours and 48 hours of treatment,the TVIL level of group A was lower than that in group V and group C( P < 0. 05). In the first day,the second day,3 ~ 5 days,the serum TVIL level increased. Con-clusion A high dose of IVIG can reduce early the serum TVIL level of patient who have neonatal AVO hemolytic disease effectively,it also can re-duce jaundice and sequela.