CAJ | 학술논문

目的研究传统方剂“四物汤”对急性辐射损伤的辅助保护作用.方法根据国家食品药品监督管理总局对抗辐射保健品的规定进行功效评价,包括外周血白细胞数、股骨有核细胞数;检测了小鼠30 d存活率.结果照射后3d与照射前1d比较,对照组的白细胞数、红细胞数和血红蛋白量均明显降低;照射后14d,与对照组比较,低剂量给药组(0.5 g/kg)的白细胞数、红细胞数及血小板数均有升高,差异有统计学意义;小鼠30 d存活率的实验表明,与对照组比较,3个给药组均延长了小鼠的存活天数.结论笔者制备的“四物汤”提取液在推荐剂量对辐射损伤具有辅助保护作用.
목적 연구전통방제“사물탕”대급성복사손상적보조보호작용.방법 근거국가식품약품감독관리총국대항복사보건품적규정진행공효평개,포괄외주혈백세포수、고골유핵세포수;검측료소서30 d존활솔.결과 조사후3d여조사전1d비교,대조조적백세포수、홍세포수화혈홍단백량균명현강저;조사후14d,여대조조비교,저제량급약조(0.5 g/kg)적백세포수、홍세포수급혈소판수균유승고,차이유통계학의의;소서30 d존활솔적실험표명,여대조조비교,3개급약조균연장료소서적존활천수.결론 필자제비적“사물탕”제취액재추천제량대복사손상구유보조보호작용.
Objective To investigate the protective activity of Siwu Decoction against acute radiation injury.Methods The population of peripheral white blood cells (WBCs) and bone marrow nucleated cells,as well as the 30 d survival rate of mice were studied in accordance with the China Food and Drug Administration regulation on anti-radiation health food.Results Compared with the control group,mice treated with Siwu Decoction showed significantly increased peripheral WBCs,red blood cells,hemoglobin,platelets,and bone marrow nucleated cells.The 30 d survival rate increased in all administration groups of mice.Conclusion Siwu Decoction extract at recommended dose exerts protective activity against radiation injury.