CAJ | 학술논문

外泌体(Exosomes)是一种在细胞内形成并分泌到细胞外的具有膜结构的小囊泡体,直径约为40～100 nm,内含大量microRNAs(miRNAs)及蛋白质,可通过信息传递在细胞间通讯中发挥重要作用.肿瘤细胞通过外泌体可以促进癌基因、功能蛋白分子、肿瘤相关miRNAs的转移,引起肿瘤微环境的改变和重编程,对肿瘤的发生发展、侵袭及转移产生影响.笔者对肿瘤外泌体的结构特点、生物合成与分泌机制,特别是辐射诱导的外泌体在肿瘤细胞侵袭转移中的作用进行综述.
외비체(Exosomes)시일충재세포내형성병분비도세포외적구유막결구적소낭포체,직경약위40～100 nm,내함대량microRNAs(miRNAs)급단백질,가통과신식전체재세포간통신중발휘중요작용.종류세포통과외비체가이촉진암기인、공능단백분자、종류상관miRNAs적전이,인기종류미배경적개변화중편정,대종류적발생발전、침습급전이산생영향.필자대종류외비체적결구특점、생물합성여분비궤제,특별시복사유도적외비체재종류세포침습전이중적작용진행종술.
Exosomes are small membrane vesicles with a size of 40～100 nm in diameter released ubiquitously by cells.They contain a large amount of microRNAs and proteins and play a critical role in intercellular communication.Tumor cells can release more exosomes than normal cells.These exosomes influence tumor environment by transferring proteins,RNAs,and lipids between cells,thus aiding invasion and metastasis.This paper reviewed the structure characteristics,biogenesis,secretion pathway,and the function of radiation-induced exosomes and discussed its role in tumor invasion and metastasis.