CAJ | 학술논문

耐辐射奇球菌(DR)是研究辐射抗性的模式生物,PprA蛋白(pleiotropic protein promoting DNA repair)是DR中一种特有的、促进DNA修复的多效蛋白.笔者对PprA蛋白在DNA损伤修复和维持基因组稳定性等方面的功能进行了综述,另通过运用生物信息学方法预测其结构域及与PprA蛋白相互作用的蛋白,进一步了解其发挥作用的机制和途径.
내복사기구균(DR)시연구복사항성적모식생물,PprA단백(pleiotropic protein promoting DNA repair)시DR중일충특유적、촉진DNA수복적다효단백.필자대PprA단백재DNA손상수복화유지기인조은정성등방면적공능진행료종술,령통과운용생물신식학방법예측기결구역급여PprA단백상호작용적단백,진일보료해기발휘작용적궤제화도경.
Deinococcus radiodurans (DR) is a model organism to study radiation resistance.PprA protein (pleiotropic protein promoting DNA repair) is a unique,pleiotropic protein promoting DNA repair in DR.This article reviewed its possible function in DNA damage repairing,maintenance of genome stability and other aspects.Furthermore,we analyze its domain of pprA genes and by bioinformatics and predict interaction protein with PprA protein,in order to predict its function and understand the mechanisms and pathways it plays.