CAJ | 학술논문

胶质瘤是最常见的颅内原发肿瘤,其病死率及致残率均较高.常规影像学方法在脑胶质瘤的术前分级、预后判断、复发与坏死的鉴别等方面存在一定不足.PET是反映肿瘤生物学特性的一种理想的非侵入性的功能显像方法,而PET/CT则实现了功能代谢图像与解剖形态图像的同机融合,为胶质瘤的诊断提供了功能代谢信息,弥补了常规影像的不足.目前已有多种分子影像途径及示踪剂用于脑胶质瘤的定位诊断及疗效监测.其中,11C-蛋氨酸(MET)PET/CT在脑胶质瘤的诊断、分级、预后评估、浸润范围的勾画、活检计划及放疗计划的制定、放疗后坏死病灶组织和肿瘤复发的鉴别诊断等方面起到重要作用.笔者就近年来11C-MET PET/CT显像在脑胶质瘤中的应用进展做一综述.
효질류시최상견적로내원발종류,기병사솔급치잔솔균교고.상규영상학방법재뇌효질류적술전분급、예후판단、복발여배사적감별등방면존재일정불족.PET시반영종류생물학특성적일충이상적비침입성적공능현상방법,이PET/CT칙실현료공능대사도상여해부형태도상적동궤융합,위효질류적진단제공료공능대사신식,미보료상규영상적불족.목전이유다충분자영상도경급시종제용우뇌효질류적정위진단급료효감측.기중,11C-단안산(MET)PET/CT재뇌효질류적진단、분급、예후평고、침윤범위적구화、활검계화급방료계화적제정、방료후배사병조조직화종류복발적감별진단등방면기도중요작용.필자취근년래11C-MET PET/CT현상재뇌효질류중적응용진전주일종술.
Cerebral glioma is the most common primary brain tumor with high rates of mortality and morbidity.Conventional imaging methods demonstrate some limitations in preoperative grading,prognostic evaluation,and differentiation between tumor recurrence and radiation necrosis for patients with cerebral gliomas.Positron emission tomography/computed tomography (PET/CT) is an ideal imaging tool for noninvasive examination of underlying tumor biology.Recently,various molecular imaging pathways and tracers for the diagnosis and therapeutic monitoring of gliomas have been studied.11C-methionine (11C-MET)PET/CT provides various advantages in diagnosing primary gliomas.These benefits include accurate diagnosis,grading,prognosis,assessment of tumor extent,biopsy,radiotherapy planning,and differentiation between radiation necrosis and tumor recurrence.This article provides an overview of the current application of 11C-MET PET/CT in the diagnosis of cerebral gliomas.