CAJ | 학술논문

万方数据

国际放射医学核医学杂志 국제방사의학핵의학잡지
INTERNATIONAL JOURNAL OF RADIATION MEDICINE AND NUCLEAR MEDICINE
2015年 2期 170-174,187 ,共6页

刘晓梅%张芳%黄建敏劉曉梅%張芳%黃建敏

류효매%장방%황건민

血管生成%血管内皮生长因子%ανβ3整合素%细胞外基质蛋白%前列腺特异性膜抗原%体层摄影术,发射型计算机,单光子血管生成%血管內皮生長因子%ανβ3整閤素%細胞外基質蛋白%前列腺特異性膜抗原%體層攝影術,髮射型計算機,單光子
혈관생성%혈관내피생장인자%ανβ3정합소%세포외기질단백%전렬선특이성막항원%체층섭영술,발사형계산궤,단광자
Angiogenesis%Vascular endothelial growth factor%ανβ3 integrin%Extracellular matrix proteins%Prostate-specific membrane antige%Tomography,emission-computed,single photon

肿瘤血管生成与肿瘤生长、转移有着密切的关系.肿瘤血管生成被各种蛋白分子调控,其中包括血管内皮生长因子、ανβ3整合素、细胞外基质蛋白、前列腺特异性膜抗原等.它们已成为肿瘤血管生成分子影像及靶向治疗研究领域的重要分子靶点.研究并利用这些蛋白分子准确无创地评估肿瘤新生血管及肿瘤抗血管生成治疗效果的成像方法,已成为现代医学影像学的一个重要课题.
종류혈관생성여종류생장、전이유착밀절적관계.종류혈관생성피각충단백분자조공,기중포괄혈관내피생장인자、ανβ3정합소、세포외기질단백、전렬선특이성막항원등.타문이성위종류혈관생성분자영상급파향치료연구영역적중요분자파점.연구병이용저사단백분자준학무창지평고종류신생혈관급종류항혈관생성치료효과적성상방법,이성위현대의학영상학적일개중요과제.
Tumor Angiogenesis is one of the key requirements of tumor growth and metastasis.Tumour-induced angiogenesis is a multistep process that controlled by growth factors,cellular receptors and adhesion molecules,such as vascular endothelial growth factor,ανβ3 integrin,extracellular matrix proteins,prostate-specific membrane antige.They have become a common molecular target which has a potential value in angiogenesis molecular imaging and therapy at present.It is an important subject of modern medical imaging in developing a new imaging method which can accurate noninvasive assessment of tumor angiogenesis and tumor anti-angiogenesis therapy effect.