中国临床新医学
中國臨床新醫學
중국림상신의학
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
2015年
5期
440-443
,共4页
黄超群%陈翔%李文君%黄海雄
黃超群%陳翔%李文君%黃海雄
황초군%진상%리문군%황해웅
新生儿%血培养%败血症%耐药性
新生兒%血培養%敗血癥%耐藥性
신생인%혈배양%패혈증%내약성
Neonate%Blood culture%Septicemia%Antibiotic resistance
目的:分析新生儿血培养病原菌分布及耐药特征,为治疗新生儿败血症、合理使用抗菌药物提供科学依据。方法回顾性统计分析2014-01~2014-12新生儿血培养的临床资料。结果新生儿血培养阳性率为6.2%(280/4512)。280份标本共检出295株病原菌,其中以革兰阳性球菌为主,共212株,占71.9%(212/295),其中凝固酶阴性葡萄球菌(CNS)占59.0%(174/295);革兰阴性杆菌69株,占23.4%(69/295);其他病原菌14株,占4.7%(14/295)。 CNS对青霉素、四环素、庆大霉素、苯唑西林耐药率为60.0%~100.0%,对万古霉素、替考拉宁、呋西地酸、呋喃妥因、米诺环素耐药率低,为0.0%~15.8%。肺炎克雷伯杆菌、大肠埃希菌对阿莫西林、头孢噻吩、头孢呋辛耐药率高,为79.5%~97.4%。结论新生儿血培养病原菌以CNS为主,CNS及革兰阴性杆菌对常用抗菌药物耐药率高,应加强耐药监测,合理使用抗菌药物。
目的:分析新生兒血培養病原菌分佈及耐藥特徵,為治療新生兒敗血癥、閤理使用抗菌藥物提供科學依據。方法迴顧性統計分析2014-01~2014-12新生兒血培養的臨床資料。結果新生兒血培養暘性率為6.2%(280/4512)。280份標本共檢齣295株病原菌,其中以革蘭暘性毬菌為主,共212株,佔71.9%(212/295),其中凝固酶陰性葡萄毬菌(CNS)佔59.0%(174/295);革蘭陰性桿菌69株,佔23.4%(69/295);其他病原菌14株,佔4.7%(14/295)。 CNS對青黴素、四環素、慶大黴素、苯唑西林耐藥率為60.0%~100.0%,對萬古黴素、替攷拉寧、呋西地痠、呋喃妥因、米諾環素耐藥率低,為0.0%~15.8%。肺炎剋雷伯桿菌、大腸埃希菌對阿莫西林、頭孢噻吩、頭孢呋辛耐藥率高,為79.5%~97.4%。結論新生兒血培養病原菌以CNS為主,CNS及革蘭陰性桿菌對常用抗菌藥物耐藥率高,應加彊耐藥鑑測,閤理使用抗菌藥物。
목적:분석신생인혈배양병원균분포급내약특정,위치료신생인패혈증、합리사용항균약물제공과학의거。방법회고성통계분석2014-01~2014-12신생인혈배양적림상자료。결과신생인혈배양양성솔위6.2%(280/4512)。280빈표본공검출295주병원균,기중이혁란양성구균위주,공212주,점71.9%(212/295),기중응고매음성포도구균(CNS)점59.0%(174/295);혁란음성간균69주,점23.4%(69/295);기타병원균14주,점4.7%(14/295)。 CNS대청매소、사배소、경대매소、분서서림내약솔위60.0%~100.0%,대만고매소、체고랍저、부서지산、부남타인、미낙배소내약솔저,위0.0%~15.8%。폐염극뢰백간균、대장애희균대아막서림、두포새분、두포부신내약솔고,위79.5%~97.4%。결론신생인혈배양병원균이CNS위주,CNS급혁란음성간균대상용항균약물내약솔고,응가강내약감측,합리사용항균약물。
Objective To investigate pathogen distribution and antibiotic resistance characteristics in neo-natal blood cultures and provide a scientific basis for the treatment of neonatal septicemia and the rational use of anti-biotics.Methods The clinical data of neonatal blood cultures were statistically analyzed retrospectively from January 2014 to December 2014.Results The positive rate of blood cultures was 6.2%(280/4512).Gram-positive coccus were the predominant, accounting for 71.9%( 212/295 ) , among which coagulase negative staphylococcus ( CNS ) were 59.0%(174/295);Gram-negative bacteria, accounted for 23.4%(69/295), other pathogens 14 strains, ac-counted for 4.7%(14/295).The resistant rates of CNS to penicillin, tetracycline, gentamicin and oxacillin were be-tween 60.0%and 100.0%.The resistant rates of CNS to vancomycin, teicoplanin, fusidicacid, nitrofurantoin, and minocycline were low, ranging from 0.0%to 15.8%.The resistant rates of Klebsiella pneumoniae and Escherichia coli to cephalothin, cefuroxime and amoxicillin were between 79.5%and 97.4%.Conclusion CNS are the predom-inant pathogens in the neonatal blood cultures and the resistance rates of CNS and some Gram-negative bacilli to some frequently-used antibacterials are high.It is necessary to take measures to monitor the drug resistance of strains and use antibacterials reasonably.