CAJ | 학술논문

目的：探讨多发性骨髓瘤（ multiple myeloma，MM）患者治疗前后血浆左旋肉碱含量及临床意义。方法选取10名正常人及36例MM患者（初诊21例，复发15例）。所有患者均接受含或不含蒽环类的方案化疗，采用高效液相色谱法检测患者及正常人的血浆左旋肉碱水平。结果无论初诊或复发患者的血浆左旋肉碱水平均低于正常人，化疗前复发患者组血浆左旋肉碱水平低于初治患者组，差异均具有统计学意义（ P＜0.05）；化疗后1 d及1周患者的血浆左旋肉碱水平均低于治疗前，含有蒽环类药物的方案可明显降低血浆左旋肉碱的水平，差异有统计学意义（ P＜0.05）。结论化疗可导致MM患者的血浆左旋肉碱水平低下，化疗过程中补充左旋肉碱具有重要的意义。
목적：탐토다발성골수류（ multiple myeloma，MM）환자치료전후혈장좌선육감함량급림상의의。방법선취10명정상인급36례MM환자（초진21례，복발15례）。소유환자균접수함혹불함은배류적방안화료，채용고효액상색보법검측환자급정상인적혈장좌선육감수평。결과무론초진혹복발환자적혈장좌선육감수평균저우정상인，화료전복발환자조혈장좌선육감수평저우초치환자조，차이균구유통계학의의（ P＜0.05）；화료후1 d급1주환자적혈장좌선육감수평균저우치료전，함유은배류약물적방안가명현강저혈장좌선육감적수평，차이유통계학의의（ P＜0.05）。결론화료가도치MM환자적혈장좌선육감수평저하，화료과정중보충좌선육감구유중요적의의。
[ Abstarct] Objecti ev To investigate the changes of plasma L-carnitine levels in the patients with multiple myeloma( MM) before and after the chemotherapy and explore their clinical significances .Mtehods The levels of plasma L-carnitine of 10 healthy people and 36 MM patients ( 21 initially-diagnosed and 15 relapsed patients with MM) were tested.All patients were given chemotherapy with or without anthracyclines and the levels of plasma L-carnitine were tested by high performance liquid chromatography.Results The levels of plasma L-carnitine of initial-ly-diagnosed and relapse patients with MM were lower than those of healthy people, but the levels of relapsed MM were lower than those initially-diagnosed MM(P<0.05);Those levels of plasma L-carnitine of MM one day and one week after chemotherapy were lower than those before chemotherapy.Chemotherapy with anthracyclines can reduce the levels of plasma L-carnitine of MM patients ( P<0.05 ) .Conclusion Chemotherapy could ruduce the levels of plasma L-carnitine of MM patients,indicating that it could be important to supplement L -carnitine during the chemo-therapy.