CAJ | 학술논문

目的：初步证实小脑-下丘脑通路调控炎性因子参与卒中后抑郁（PSD）的发生。方法将160只雄性（SD）大鼠随机分为假手术组、卒中组、PSD组、海人酸（KA）损毁小脑顶核组、电损毁小脑上脚交叉（xSCP）组。进行行为学观察和测试，并取海马组织采用免疫组化方法分析其IL?1β和TNF?α的表达。结果与假手术组及卒中组相比，PSD组TNF?α、IL?1β含量明显增加；而KA组与xSCP组的大鼠炎性因子表达与PSD组变化一致，3组之间无统计学差异。结论小脑顶核可能通过小脑-下丘脑通路调控炎性因子进而参与卒中后抑郁的发生。
목적：초보증실소뇌-하구뇌통로조공염성인자삼여졸중후억욱（PSD）적발생。방법장160지웅성（SD）대서수궤분위가수술조、졸중조、PSD조、해인산（KA）손훼소뇌정핵조、전손훼소뇌상각교차（xSCP）조。진행행위학관찰화측시，병취해마조직채용면역조화방법분석기IL?1β화TNF?α적표체。결과여가수술조급졸중조상비，PSD조TNF?α、IL?1β함량명현증가；이KA조여xSCP조적대서염성인자표체여PSD조변화일치，3조지간무통계학차이。결론소뇌정핵가능통과소뇌-하구뇌통로조공염성인자진이삼여졸중후억욱적발생。
Objective To preliminarily proved that the cerebellar hypothalamic pathways regulate inflammatory cytokines involved in post?stroke depression(post?stroke depression,PSD). Methods 160 male(Sprague?Dawley,SD)rats were randomly divided into sham operation group,the stroke group,PSD group,kainic acid(kainic acid,KA)damage of cerebellar fastigial nucleus group,electrical damaged decussation of superior cer?ebellar peduncle(superior cerebellar peduncle,xSCP)group. The behavioral observation were observed and expression of IL?1βand TNF?αin hip?pocampus by immunohistochemistry. Results Compared with the sham operation group and stroke group,PSD group,TNF?α,IL?1βcontent signif?icantly increased;and the factor of rats with KA group and xSCP group expression consistent with PSD group,there was no significant difference among the three groups. Conclusion The cerebellar fastigial nuclear may through the cerebellar hypothalamic pathways regulate inflammatory cyto?kines and participate in post stroke depression.