CAJ | 학술논문

目的：探讨早产儿先天性甲状腺功能减低症（CH）筛查效果。方法对广州市新生儿疾病筛查中心208713例新生儿 CH 的筛查结果进行分析，其中早产儿11589例，足月儿197124例。比较早产儿组与足月儿组 CH 筛查阳性率和发病率的差异，评价早产儿 CH 的筛查效率。结果208713例新生儿 CH 初筛阳性2895例，初筛阳性率为1．39％，共检出 CH 患儿123例，发病率为11697。其中，早产儿组初筛阳性124例，初筛阳性率为1．06％，确诊14例，发病率为1828；足月儿组初筛阳性2771例，初筛阳性率为1.41％，确诊109例，发病率为11809。早产儿组初筛阳性率低于足月儿组（χ2＝4．89，P ＜0．05），发病率高于足月儿组（χ2＝8．26，P ＜0．05）。结论早产儿 CH 发病率高；新生儿疾病筛查是早产儿 CH 早期诊断的有效措施之一。
목적：탐토조산인선천성갑상선공능감저증（CH）사사효과。방법대엄주시신생인질병사사중심208713례신생인 CH 적사사결과진행분석，기중조산인11589례，족월인197124례。비교조산인조여족월인조 CH 사사양성솔화발병솔적차이，평개조산인 CH 적사사효솔。결과208713례신생인 CH 초사양성2895례，초사양성솔위1．39％，공검출 CH 환인123례，발병솔위11697。기중，조산인조초사양성124례，초사양성솔위1．06％，학진14례，발병솔위1828；족월인조초사양성2771례，초사양성솔위1.41％，학진109례，발병솔위11809。조산인조초사양성솔저우족월인조（χ2＝4．89，P ＜0．05），발병솔고우족월인조（χ2＝8．26，P ＜0．05）。결론조산인 CH 발병솔고；신생인질병사사시조산인 CH 조기진단적유효조시지일。
Objective To discuss the effect of neonatal congenital hypothyroidism (CH)screening in preterm infants.Methods The result of 208 713 cases neonatal congenital hypothyroidism screening in Guangzhou neonatal screening center were analyzed,including 11589 cases preterm infant and 197 124 cases of full term.The difference of screening positive rate and incidence between preterm infants and full term infants group were compared and the efficiency of preterm infants congenital hypothyroidism screening were estimated.Results A total of 208 713 newborns were screened and the screening positive rate was 1.39%.123 cases were confirmed positive for CH and the incidence rate was 1 /1 697.124 cases were screening positive in preterm infants and the screening posi-tive rate was 1.06%.14 cases were confirmed positive for CH and the incidence rate was 1 /828 in preterm infants group.2 771 cases were screening positive in full term infants and the screening positive rate was 1.41%.109 cases were confirmed positive for CH and the incidence rate was 1 /1 809 in full term group.The screening positive rate was lower and the incidence rate of preterm infants group(χ2 =4.89,P <0.05)was higher than that of the full term infants group(χ2 =8.26,P <0.05).Conclusion The incidence rate of congenital hypothyroidism is higher in preterm infants.Neonatal screening is an effective measure for early diagnosis of preterm infants congenital hypothyroidism.