CAJ | 학술논문

目的：探讨不同方案同步放化疗治疗中晚期宫颈癌的临床效果及安全性。方法选取96例中晚期宫颈癌患者作为研究对象，根据随机数字表法分为观察组和对照组，每组48例。观察组采用放疗同步奈达铂化疗治疗，对照组采用放疗同步顺铂联合氟尿嘧啶化疗治疗。比较两组患者近期疗效、远处转移率、盆腔复发率、4年生存率及毒副作用。结果观察组治疗有效率为91．8％，对照组为87．5％，差异无统计学意义（χ2＝0．4465，P ＞0．05）；两组远处转移率、盆腔复发率及4年生存率差异均无统计学意义（χ2＝1．2000、1．3380、1．5238，均 P ＞0．05）；观察组Ⅲ度白细胞减少发生率为4．2％，对照组为22．9％，观察组Ⅲ度白细胞减少发生率低于对照组（χ2＝7．2067，P ＜0．05）；观察组Ⅲ度胃肠道反应发生率为20．8％，对照组为47.9％，观察组Ⅲ度胃肠道反应发生率低于对照组（χ2＝7．8038，P ＜0．05）。结论两种方案同步放化疗治疗中晚期宫颈癌临床疗效相当，患者对奈达铂同步放化疗治疗耐受性更好，安全性高，值得在临床上推广应用。
목적：탐토불동방안동보방화료치료중만기궁경암적림상효과급안전성。방법선취96례중만기궁경암환자작위연구대상，근거수궤수자표법분위관찰조화대조조，매조48례。관찰조채용방료동보내체박화료치료，대조조채용방료동보순박연합불뇨밀정화료치료。비교량조환자근기료효、원처전이솔、분강복발솔、4년생존솔급독부작용。결과관찰조치료유효솔위91．8％，대조조위87．5％，차이무통계학의의（χ2＝0．4465，P ＞0．05）；량조원처전이솔、분강복발솔급4년생존솔차이균무통계학의의（χ2＝1．2000、1．3380、1．5238，균 P ＞0．05）；관찰조Ⅲ도백세포감소발생솔위4．2％，대조조위22．9％，관찰조Ⅲ도백세포감소발생솔저우대조조（χ2＝7．2067，P ＜0．05）；관찰조Ⅲ도위장도반응발생솔위20．8％，대조조위47.9％，관찰조Ⅲ도위장도반응발생솔저우대조조（χ2＝7．8038，P ＜0．05）。결론량충방안동보방화료치료중만기궁경암림상료효상당，환자대내체박동보방화료치료내수성경호，안전성고，치득재림상상추엄응용。
Objective To explore the efficacy and safety of different synchronization chemotherapy for mid-dle -advanced cervical cancer.Methods 96 patients with middle -advanced cervical cancer were selected as the research objects.According to the digital table,they were divided into the observation group and control group, 48 cases in each group.The observation group was used radiotherapy combined with nedaplatin chemotherapy,The control group was used radiotherapy cisplatin and 5 -fluorouracil chemotherapy,The efficacy,transfer rate,pelvic recurrence rate,4 year survival rate and side effect of the two groups were compared.Results The effective rate in the observation group was 91.8%,87.5% in the control group,there was no significant difference between the two groups (χ2 =0.446 5,P >0.05);The rate of distant metastasis,pelvic recurrence and 4 year survival rates between the two groups had no significant difference(χ2 =1.200 0,1.338 0,1.523 8,all P >0.05);The incidence rate of Ⅲneutropenia in the observation group was 4.2%,which was lower than 22.9% in the control group(χ2 =7.206 7,P <0.05);The incidence rate Ⅲ gastrointestinal reaction of the observation group was 20.8%,which was lower than 47.9% of the control group(χ2 =7.803 8,P <0.05).Conclusion The two schemes of radiotherapy clinical cura-tive effect of chemotherapy in the treatment of middle -advanced cervical cancer has a same effect,and the patients of nedaplatin chemoradiotherapy has better tolerability,safety,which is worth of clinical application.