解放军医药杂志
解放軍醫藥雜誌
해방군의약잡지
MEDICAL&PHARMACEUTICAL JOURNAL OF CHINESE PEOPLE'S LIBERATION ARMY
2015年
5期
56-60
,共5页
宫颈肿瘤%酪蛋白激酶类%β-连环蛋白%凋亡抑制蛋白质类%存活素
宮頸腫瘤%酪蛋白激酶類%β-連環蛋白%凋亡抑製蛋白質類%存活素
궁경종류%락단백격매류%β-련배단백%조망억제단백질류%존활소
Uterine cervical neoplasms%Casein kinases%β-catenin%Inhibitor of apoptosis proteins%Survivin
目的：研究酪蛋白激酶2α(Ck2α)、β-连环蛋白(β-catenin)、凋亡抑制蛋白(c-IAP1)及存活素(sur-vivin)在宫颈癌组织中的表达情况及其相关性,探讨四者联合检测在宫颈癌诊断中的临床意义。方法选择重庆市大足区人民医院收治的宫颈癌74例(宫颈癌组)、宫颈上皮内瘤变(CIN)83例(CIN 组)和子宫肌瘤50例(对照组),采用免疫组化法检测3组宫颈组织中 Ck2α、β-catenin、c-IAP1及 survivin 表达情况,分析其相关性及与临床病理特征的关系。结果宫颈癌组 Ck2α、β-catenin、c-IAP1、survivin 阳性表达率高于 CIN 组和对照组,且其表达与肿瘤分化程度及 FIGO 分期有关( P <0．05),Ck2α阳性表达率与β-catenin、c-IAP1、survivin 表达水平均呈正相关( r =0.570、0．391、0.476,P <0．05),Ck2α、β-catenin、c-IAP1、survivin 阳性表达率与分化程度呈负相关(r =-0.325、-0.633、-0．397、-0.324,P <0．05),与 FIGO 分期呈正相关(r =0.349、0.634、0.621、0.391,P <0．05)。结论 Ck2α、β-catenin、c-IAP1及 survivin 在宫颈癌组织中阳性表达率较高,其与宫颈癌的发生、发展有关,四者联合检测对早期诊断宫颈癌及临床治疗有重要意义。
目的：研究酪蛋白激酶2α(Ck2α)、β-連環蛋白(β-catenin)、凋亡抑製蛋白(c-IAP1)及存活素(sur-vivin)在宮頸癌組織中的錶達情況及其相關性,探討四者聯閤檢測在宮頸癌診斷中的臨床意義。方法選擇重慶市大足區人民醫院收治的宮頸癌74例(宮頸癌組)、宮頸上皮內瘤變(CIN)83例(CIN 組)和子宮肌瘤50例(對照組),採用免疫組化法檢測3組宮頸組織中 Ck2α、β-catenin、c-IAP1及 survivin 錶達情況,分析其相關性及與臨床病理特徵的關繫。結果宮頸癌組 Ck2α、β-catenin、c-IAP1、survivin 暘性錶達率高于 CIN 組和對照組,且其錶達與腫瘤分化程度及 FIGO 分期有關( P <0．05),Ck2α暘性錶達率與β-catenin、c-IAP1、survivin 錶達水平均呈正相關( r =0.570、0．391、0.476,P <0．05),Ck2α、β-catenin、c-IAP1、survivin 暘性錶達率與分化程度呈負相關(r =-0.325、-0.633、-0．397、-0.324,P <0．05),與 FIGO 分期呈正相關(r =0.349、0.634、0.621、0.391,P <0．05)。結論 Ck2α、β-catenin、c-IAP1及 survivin 在宮頸癌組織中暘性錶達率較高,其與宮頸癌的髮生、髮展有關,四者聯閤檢測對早期診斷宮頸癌及臨床治療有重要意義。
목적：연구락단백격매2α(Ck2α)、β-련배단백(β-catenin)、조망억제단백(c-IAP1)급존활소(sur-vivin)재궁경암조직중적표체정황급기상관성,탐토사자연합검측재궁경암진단중적림상의의。방법선택중경시대족구인민의원수치적궁경암74례(궁경암조)、궁경상피내류변(CIN)83례(CIN 조)화자궁기류50례(대조조),채용면역조화법검측3조궁경조직중 Ck2α、β-catenin、c-IAP1급 survivin 표체정황,분석기상관성급여림상병리특정적관계。결과궁경암조 Ck2α、β-catenin、c-IAP1、survivin 양성표체솔고우 CIN 조화대조조,차기표체여종류분화정도급 FIGO 분기유관( P <0．05),Ck2α양성표체솔여β-catenin、c-IAP1、survivin 표체수평균정정상관( r =0.570、0．391、0.476,P <0．05),Ck2α、β-catenin、c-IAP1、survivin 양성표체솔여분화정도정부상관(r =-0.325、-0.633、-0．397、-0.324,P <0．05),여 FIGO 분기정정상관(r =0.349、0.634、0.621、0.391,P <0．05)。결론 Ck2α、β-catenin、c-IAP1급 survivin 재궁경암조직중양성표체솔교고,기여궁경암적발생、발전유관,사자연합검측대조기진단궁경암급림상치료유중요의의。
Objective To study the expressions and correlations of casein kinase2α (Ck2α), β-catenin, c-in-hibitor of apoptosis protein1 (c-IAP1) and survivin in cervical cancer tissues and to analyze the clinical value of com-bined detection in diagnosis of cervical cancer. Methods A total of 74 patients with cervical cancer (CC group), 83 patients with cervical intraepithelial neoplasia (CIN group) and 50 women with vterine fibroids (control group) were re-cruited in this study. Immunohistochemistry staining was used to detect the Ck2α, β-catenin, c-IAP1 and survivin ex-pressions in the three groups, and the correlations and clinicopathological characteristics were also analyzed. Results The positive expression rates of Ck2α, β-catenin, c-IAP1 and survivin in CC group were significantly higher than those in CIN and control groups, and the expression levels were related with differential degrees of neoplasm and FIGO stages (P < 0. 05). In CC group, the positive expression rate of Ck2α was positively correlated with the expression levels of β-catenin, c-IAP1 and survivin (r = 0. 570, 0. 391, 0. 476, P < 0. 05), and the positive expression rates of Ck2α, β-cate-nin, c-IAP1 and survivin were negatively correlated with differential degrees ( r = - 0. 325, - 0. 633, - 0. 397, -0. 324, P < 0. 05), but the rates were positively correlated with FIGO stages (r = 0. 349, 0. 634, 0. 621, 0. 391, P <0. 05). Conclusion The Ck2α, β-catenin, c-IAP1 and survivin have high positive expression rates in cervical cancer tissues, and the rate are correlated with the occurrence and development of cervical cancer, therefore the combined detec-tion has important clinical value in early diagnosis of cervical cancer.
