CAJ | 학술논문

目的：探讨联合检测癌胚抗原(CEA)、甲胎蛋白(AFP)、癌糖类相关抗原(CA19-9)对结直肠癌的诊断价值。方法选择广州医科大学附属深圳沙井医院2011年1月—2013年12月收治的60例结直肠癌，观察不同部位、不同分化程度及不同 Dukes 分期结直肠癌 CEA、AFP、CA19-9的表达水平，分析其联合检测对结直肠癌诊断的敏感性和特异度。结果 Dukes C + D 期 CEA、AFP、CA19-9阳性率高于 Dukes A + B 期(P <0．01)。 CEA、AFP、CA19-9联合检测结直肠癌敏感性均高于单项检测，且3项联合检测在结直肠癌 Dukes C + D 期的敏感性高于 Dukes A + B 期(P <0．01)，但特异度比较差异无统计学意义(P >0．05)。结论 CEA、AFP、CA19-9联合检测可提高结直肠癌诊断阳性率，且对 Dukes C、D 期诊断价值较高，有助于判断结直肠癌病理分期、估计预后并指导手术范围。
목적：탐토연합검측암배항원(CEA)、갑태단백(AFP)、암당류상관항원(CA19-9)대결직장암적진단개치。방법선택엄주의과대학부속심수사정의원2011년1월—2013년12월수치적60례결직장암，관찰불동부위、불동분화정도급불동 Dukes 분기결직장암 CEA、AFP、CA19-9적표체수평，분석기연합검측대결직장암진단적민감성화특이도。결과 Dukes C + D 기 CEA、AFP、CA19-9양성솔고우 Dukes A + B 기(P <0．01)。 CEA、AFP、CA19-9연합검측결직장암민감성균고우단항검측，차3항연합검측재결직장암 Dukes C + D 기적민감성고우 Dukes A + B 기(P <0．01)，단특이도비교차이무통계학의의(P >0．05)。결론 CEA、AFP、CA19-9연합검측가제고결직장암진단양성솔，차대 Dukes C、D 기진단개치교고，유조우판단결직장암병리분기、고계예후병지도수술범위。
Objective To study the value of combined detection of carcinoembryonic antigen (CEA), alpha fe-toprotein (AFP) and carbohydrate antigen 19-9 (CA19-9) in diagnosis of colorectal cancer. Methods A total of 60 colorectal cancer inpatients during January 2011 and December 2013 were recruited in this study, and levels of serum CEA, AFP and CA19-9 expressions of different tumor parts, differentiated degrees and Dukes clinical stages were ob-served, and then the sensibility and specificity of combined detection for colorectal cancer were analyzed. Results The positive rates of CEA, AFP and CA19-9 in Dukes C + D stage were statistically higher than those in Dukes A + B stage (P < 0. 01). The combined detection sensitivity of CEA, AFP and CA19-9 in diagnosis of colorectal cancer was stronger than those by CEA, AFP and CA19-9 single detection, and the combined detection sensitivity in Dukes C + D stage was stronger than that in Dukes A + B stage (P < 0. 01), but there were no statistically significant in specificity values (P >0. 05). Conclusion The combined detection of CA19-9, AFP and CEA can increase the positive rate in diagnosis of colorectal cancer. The diagnosed value of the combined detection in patients with Dukes (C + D) is high and helpful in judging the pathological stage, assessing prognosis and guiding operational range.