CAJ | 학술논문

目的：探讨2型糖尿病患者（T2MD）血清丙氨酸氨基转移酶（ALT）水平与糖脂代谢水平的关系。方法2012年1月至2014年1月选取本院健康管理中心体检的68例 T2MD患者为研究对象，另选取同期在本院进行葡萄糖耐量试验（OGTT）试验的128例体检者为对照组，根据OGGT试验将体检者分为糖耐量减低组（IGT）60例以及血糖正常组（NGT）组。测定三组血清ALT、空腹血糖（FBG）、糖化血红蛋白（HbA1c）、空腹胰岛素（FINS）、三酰甘油（TG）、总胆固醇（TC）、低密度蛋白（LCL‐C）、高密度蛋白（HCL‐C）、载脂蛋白B（APOB）、载脂蛋白 A1（APOA1），并计算各组体质指数（BMI）及胰岛素抵抗指数（HOMA‐IR）。采用Pearson直线相关性分析ALT与IR的关系，Logistic多因素回归分析ALT与HOMA‐IR的关系。结果 T2MD组患者血清ALT、FBG、HbA1c、FINS、TG、TC、LCL‐C、APOB、HOMA‐IR水平显著高于IGT组及NGT组，而IGT组上述各指标高于NGT组，而 HCL‐C、APOA1水平显著低于IGT组及NGT组，差异有统计学意义（P＜0．05）。经Pearson相关分析可知，血清ALT与FINS、FBG、HbA1c、APOB、LCL‐C、HOMA‐IR呈正相关（P＜0．05），而与APOA1呈负相关（P＜0．05），与TG、TC、HCL‐C无相关性（P＞0．05）。Logistic多因素回归分析表明，ALT、FBG、HbA1、、LCL‐C是 HOMA‐IR的独立危险因素。结论血清ALT升高与T2MD的发生具有密切的关系，且这种关系可能与血脂血糖及胰岛素分泌功能相关。
목적：탐토2형당뇨병환자（T2MD）혈청병안산안기전이매（ALT）수평여당지대사수평적관계。방법2012년1월지2014년1월선취본원건강관리중심체검적68례 T2MD환자위연구대상，령선취동기재본원진행포도당내량시험（OGTT）시험적128례체검자위대조조，근거OGGT시험장체검자분위당내량감저조（IGT）60례이급혈당정상조（NGT）조。측정삼조혈청ALT、공복혈당（FBG）、당화혈홍단백（HbA1c）、공복이도소（FINS）、삼선감유（TG）、총담고순（TC）、저밀도단백（LCL‐C）、고밀도단백（HCL‐C）、재지단백B（APOB）、재지단백 A1（APOA1），병계산각조체질지수（BMI）급이도소저항지수（HOMA‐IR）。채용Pearson직선상관성분석ALT여IR적관계，Logistic다인소회귀분석ALT여HOMA‐IR적관계。결과 T2MD조환자혈청ALT、FBG、HbA1c、FINS、TG、TC、LCL‐C、APOB、HOMA‐IR수평현저고우IGT조급NGT조，이IGT조상술각지표고우NGT조，이 HCL‐C、APOA1수평현저저우IGT조급NGT조，차이유통계학의의（P＜0．05）。경Pearson상관분석가지，혈청ALT여FINS、FBG、HbA1c、APOB、LCL‐C、HOMA‐IR정정상관（P＜0．05），이여APOA1정부상관（P＜0．05），여TG、TC、HCL‐C무상관성（P＞0．05）。Logistic다인소회귀분석표명，ALT、FBG、HbA1、、LCL‐C시 HOMA‐IR적독립위험인소。결론혈청ALT승고여T2MD적발생구유밀절적관계，차저충관계가능여혈지혈당급이도소분비공능상관。
Objective To investigate the relationship between the levels of type 2 diabetes mellitus (T2MD) ser‐um alanine aminotransferase (ALT) and levels of glucose and lipid metabolism .Method 68 cases of Endocrinology T2MD patients were selected for the study from January 2012 to January 2014 .128 cases of period were divided into the groups with impaired glucose tolerance (IGT ,n=60) and normal glucose group (NGT ,n=68) accord to glu‐cose tolerance test (OGTT).The levels of serum ALT ,fasting blood glucose (FBG),glycated hemoglobin (HbA1c) ,fasting insulin (FINS) ,triglyceride (TG) ,total cholesterol (TC) ,low‐density protein (LCL‐C) ,high density protein ( HCL‐C) ,apolipoprotein B (APOB) ,apolipoprotein A1 (APOA1) ,and calculate the body mass index of each group (BMI) and insulin resistance index (HOMA‐IR) of three groups were compared .Logistic re‐gression of the relationship was analyzed between the FFA and HOMA‐IR by using the straight‐line relationship be‐tween the Pearson correlation analysis of ALT and IR .Result The levels of serum ALT patients ,FBG ,HbA1c , FINS ,TG ,TC ,LCL‐C ,APOB ,HOMA‐IR of T2MD groups were higher than IGT group and NGT group ,while each of the above indicators higher than the IGT group NGT group ,while HCL‐C ,APOA1 were significantly low‐er than IGT group and the NGT group ,the difference was statistically significant (P<0 .05) .By Pearson correla‐tion factor analysis ,serum ALT and FINS ,FBG ,HbA1c ,APOB ,LCL‐C ,HOMA‐IR was positively correlated (P<0 .05) ,whereas the APOA1 negatively correlated (P<0 .05) ,and TG ,TC ,HCL‐C no correlation (P>0 .05) . After Logistic regression analysis shows ,ALT ,FBG ,HbA1 ,LCL‐C was an independent risk factor for HOMA‐IR .Conclusion Serum ALT elevations occurred with T2MD has a close relationship ,and this relationship may be as‐sociated with blood lipid and glucose and insulin secretion .