浙江医学教育
浙江醫學教育
절강의학교육
Zhejiang Medical Education
2015年
3期
38-40,57
,共4页
赵宏光%陈文虎%童佳丽%庄成郁%景益佳%蔡裘毅聪%王黎芳
趙宏光%陳文虎%童佳麗%莊成鬱%景益佳%蔡裘毅聰%王黎芳
조굉광%진문호%동가려%장성욱%경익가%채구의총%왕려방
血清血蛋白%食管鳞癌%转移%预后
血清血蛋白%食管鱗癌%轉移%預後
혈청혈단백%식관린암%전이%예후
esophageal squamous cell carcinoma%serum ferritin%metastasis%prognostic factor
目的：探讨食管鳞癌患者（esophageal squamous cell carcinoma ，ESCC ）血清铁蛋白（serum ferritsn ，SF ）检测的临床意义。方法：回顾性分析食管鳞癌行SF检测的患者ESCC314例。先以正常值上限为界（274．66 ng／ml ）统计SF与ESCC临床病理参数及手术患者预后的关系。然后，以ROC曲线分别确定SF在ESCC淋巴结转移、血行转移、5年生存期的最适临界值。根据最适临界值，分别以卡方检验及Kaplan–Meier法统计SF与ESCC临床病理参数及预后的关系。以Cox回归评价预后因素。结果：以274．66 ng／ml为界，SF与各个临床病理参数及预后均无关。SF在ESCC血行转移的最适临界值为216．835ng／ml ，对应的敏感度为66．7％，特异度为58．7％。以216．835 ng／ml为界，SF仅与血行转移相关，与手术治疗的预后无关。结论：SF与ESCC血行转移相关，216．835ng／ml可以作为SF判断ESCC血行转移的参考指标。
目的：探討食管鱗癌患者（esophageal squamous cell carcinoma ，ESCC ）血清鐵蛋白（serum ferritsn ，SF ）檢測的臨床意義。方法：迴顧性分析食管鱗癌行SF檢測的患者ESCC314例。先以正常值上限為界（274．66 ng／ml ）統計SF與ESCC臨床病理參數及手術患者預後的關繫。然後，以ROC麯線分彆確定SF在ESCC淋巴結轉移、血行轉移、5年生存期的最適臨界值。根據最適臨界值，分彆以卡方檢驗及Kaplan–Meier法統計SF與ESCC臨床病理參數及預後的關繫。以Cox迴歸評價預後因素。結果：以274．66 ng／ml為界，SF與各箇臨床病理參數及預後均無關。SF在ESCC血行轉移的最適臨界值為216．835ng／ml ，對應的敏感度為66．7％，特異度為58．7％。以216．835 ng／ml為界，SF僅與血行轉移相關，與手術治療的預後無關。結論：SF與ESCC血行轉移相關，216．835ng／ml可以作為SF判斷ESCC血行轉移的參攷指標。
목적：탐토식관린암환자（esophageal squamous cell carcinoma ，ESCC ）혈청철단백（serum ferritsn ，SF ）검측적림상의의。방법：회고성분석식관린암행SF검측적환자ESCC314례。선이정상치상한위계（274．66 ng／ml ）통계SF여ESCC림상병리삼수급수술환자예후적관계。연후，이ROC곡선분별학정SF재ESCC림파결전이、혈행전이、5년생존기적최괄림계치。근거최괄림계치，분별이잡방검험급Kaplan–Meier법통계SF여ESCC림상병리삼수급예후적관계。이Cox회귀평개예후인소。결과：이274．66 ng／ml위계，SF여각개림상병리삼수급예후균무관。SF재ESCC혈행전이적최괄림계치위216．835ng／ml ，대응적민감도위66．7％，특이도위58．7％。이216．835 ng／ml위계，SF부여혈행전이상관，여수술치료적예후무관。결론：SF여ESCC혈행전이상관，216．835ng／ml가이작위SF판단ESCC혈행전이적삼고지표。
Objective]To investigate the clinical significance of serum ferritin (SF) in esophageal squamous cell carcinoma (ES-CC) .[Method]We retrospectively analyzed SF level in 314 ESCC patients .With the upper limit of normal value (274 .66ng/ml ) as boundary value ,the relations between SF and ESCC clinicopathological factors or prognosis were analyzed firstly .Then , the cut off values of SF were delimited according to lymph node metastasis ,hematogenic metastasis and 5 year survival .Based on these cut off values ,the relations between SF and clinicopathological factors or prognosis were analyzed withχ2 test and Ka-plan Meier method respectively .Cox’s regression was performed to evaluate the prognostic parameters .[Result]There were no significant differences between SF and clinicopathological factors with 274 .66 ng/ml as the boundary value .The optimal cut off value of SF was 216 .835ng/ml in hematogenic metastasis .The corresponding sensitivity or specificity was 66 .7% or 58 .7% , respectively .SF was only associated with hematogenous metastasis .[Conclusion]SF could predict hematogenic metastasis with the cut-off value 216 .835ng/ml .
