南京中医药大学学报
南京中醫藥大學學報
남경중의약대학학보
JOURNAL OF NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
2015年
3期
298-300
,共3页
安脑宁颗粒%高血压脑出血%超敏 C 反应蛋白%白细胞介素 1β%基质金属蛋白酶-9
安腦寧顆粒%高血壓腦齣血%超敏 C 反應蛋白%白細胞介素 1β%基質金屬蛋白酶-9
안뇌저과립%고혈압뇌출혈%초민 C 반응단백%백세포개소 1β%기질금속단백매-9
Annaoning granule%hypertensive intracerebral hemorrhage%hypersensitive C-reactive protein%interleukin-1β%matrix metalloproteinase-9
目的：探讨安脑宁颗粒对高血压脑出血（HICH）患者血清超敏 C 反应蛋白（hs-CRP）、白细胞介素1β（IL-1β）及基质金属蛋白酶9（MMP-9）的影响。方法将90例高血压脑出血患者随机分为对照组、治疗组及阳性对照组各30例，对照组给予降颅压、止血药等常规治疗，治疗组则在常规治疗基础上加用安脑宁颗粒，阳性对照组则在常规治疗基础上加用乌司他丁，于治疗前、治疗第3、7、14天采集各组患者血清，采用免疫比浊法检测 hs-CRP，电化学发光法检测 IL-1β，酶联免疫吸附法检测MMP-9，并记录斯堪的纳维亚卒中量表（SSS）评分。结果与对照组比较，治疗组和阳性对照组的 hs-CRP、IL-1β及 MMP-9均显著下降，第14天 SSS 评分均升高（P ＜0．05～0．01），治疗组与阳性对照组之间比较差异无统计学意义（P ＞0．05）。结论安脑宁颗粒对高血压脑出血具有显著治疗作用，有较好的脑保护作用。
目的：探討安腦寧顆粒對高血壓腦齣血（HICH）患者血清超敏 C 反應蛋白（hs-CRP）、白細胞介素1β（IL-1β）及基質金屬蛋白酶9（MMP-9）的影響。方法將90例高血壓腦齣血患者隨機分為對照組、治療組及暘性對照組各30例，對照組給予降顱壓、止血藥等常規治療，治療組則在常規治療基礎上加用安腦寧顆粒，暘性對照組則在常規治療基礎上加用烏司他丁，于治療前、治療第3、7、14天採集各組患者血清，採用免疫比濁法檢測 hs-CRP，電化學髮光法檢測 IL-1β，酶聯免疫吸附法檢測MMP-9，併記錄斯堪的納維亞卒中量錶（SSS）評分。結果與對照組比較，治療組和暘性對照組的 hs-CRP、IL-1β及 MMP-9均顯著下降，第14天 SSS 評分均升高（P ＜0．05～0．01），治療組與暘性對照組之間比較差異無統計學意義（P ＞0．05）。結論安腦寧顆粒對高血壓腦齣血具有顯著治療作用，有較好的腦保護作用。
목적：탐토안뇌저과립대고혈압뇌출혈（HICH）환자혈청초민 C 반응단백（hs-CRP）、백세포개소1β（IL-1β）급기질금속단백매9（MMP-9）적영향。방법장90례고혈압뇌출혈환자수궤분위대조조、치료조급양성대조조각30례，대조조급여강로압、지혈약등상규치료，치료조칙재상규치료기출상가용안뇌저과립，양성대조조칙재상규치료기출상가용오사타정，우치료전、치료제3、7、14천채집각조환자혈청，채용면역비탁법검측 hs-CRP，전화학발광법검측 IL-1β，매련면역흡부법검측MMP-9，병기록사감적납유아졸중량표（SSS）평분。결과여대조조비교，치료조화양성대조조적 hs-CRP、IL-1β급 MMP-9균현저하강，제14천 SSS 평분균승고（P ＜0．05～0．01），치료조여양성대조조지간비교차이무통계학의의（P ＞0．05）。결론안뇌저과립대고혈압뇌출혈구유현저치료작용，유교호적뇌보호작용。
ABSTRACT:OBJECTIVE To explore the effect of Annaoning granule on hypersensitive C-reactive protein(hs-CRP),inter-leukin-1β(IL-1β),and matrix metalloproteinase-9(MMP-9) in the serum of patients with hypertensive intracerebral hemor-rhage(HICH).METHODS 90 patients with HICH were randomly divided into 3 groups:the control group,the treatment group and the positive control group.The control group was given regular treatment with reducingintracranial pressure and taking hemostatic drug.The treatment group and the positive control group were given Annaoning granule and Ulinastatin re-spectively on the base of regular treatment.The blood samples of patients were collected before treatment and 3 days,7 days, 14 days after treatment.The serum hs-CRP was measured with immunoturbidimetry,the IL-1βwas measured with electro-chemiluminescence(ECLIA),and the MMP-9 was measured with enzyme linked immunosorbent assay(ELISA).The scores of Scandinavian Stroke Scale(SSS) were recorded in the three groups.RESULTS Compared with the control group,the serum levels of hs-CRP,IL-1β,MMP-9 in the treatment group and the positive control group were obviously decreased,and the SSS scores were increased on the 14th day(P <0.01~0.05).The comparison between the treatment group and the positive control group had no statistic significance(P >0.05).CONCLUSION Annaoning granule shows significant efficacy in treating HICH and advantage in cerebral protection.
