CAJ | 학술논문

目的：观察益气化瘀方预防子宫内膜异位症术后复发的疗效。方法选取2013年1月至2014年9月在湖北省中医院妇产科、江汉大学医院妇产科门诊就诊的子宫内膜异位症术后患者65名，随机分成中药组（32例）和西药组（33例）。中药组采用益气化瘀方，西药组采用孕三烯酮，3月为1个疗程，用1个疗程。分别于疗程结束和停药6月时观察患者用药的副反应、月经情况和停药后的复发率、痛经复现情况、妊娠情况、癌抗原 CA125等变化。结果①复发率、CA125值变化：2组无显著性差异（P ＞0．05）。②术后痛经复现情况、术后妊娠率、药物副反应：2组具有显著性差异（P ＜0．05），中药组优于西药组。③用药期间的月经情况：2组具有显著性差异（P ＜0．05～0．01），中药组优于对照组。结论在复发率、降低 CA125值方面益气化瘀方与孕三烯酮疗效相当。在提高妊娠率、降低痛经复现率和痛经评分方面益气化瘀方疗效明显优于孕三烯酮。在用药后益气化瘀方具有副反应发生率低，不造成闭经，调经助孕等优势。
목적：관찰익기화어방예방자궁내막이위증술후복발적료효。방법선취2013년1월지2014년9월재호북성중의원부산과、강한대학의원부산과문진취진적자궁내막이위증술후환자65명，수궤분성중약조（32례）화서약조（33례）。중약조채용익기화어방，서약조채용잉삼희동，3월위1개료정，용1개료정。분별우료정결속화정약6월시관찰환자용약적부반응、월경정황화정약후적복발솔、통경복현정황、임신정황、암항원 CA125등변화。결과①복발솔、CA125치변화：2조무현저성차이（P ＞0．05）。②술후통경복현정황、술후임신솔、약물부반응：2조구유현저성차이（P ＜0．05），중약조우우서약조。③용약기간적월경정황：2조구유현저성차이（P ＜0．05～0．01），중약조우우대조조。결론재복발솔、강저 CA125치방면익기화어방여잉삼희동료효상당。재제고임신솔、강저통경복현솔화통경평분방면익기화어방료효명현우우잉삼희동。재용약후익기화어방구유부반응발생솔저，불조성폐경，조경조잉등우세。
ABSTRACT:OBJECTIVE To explore the clinical effect of Yiqi Huayu Fang in preventing postoperative recurrence of endome-triosis.METHODS Sixty-five cases who visited gynecology and obstetrics department of both Hubei University of Chinese Medicine and Jianghan University after endometriosis operation from January 2013 to September 2014 were selected and ran-domly divided into Chinese materia medica group(32 cases)and western medication group(33 cases).The former was treated with Yiqi Huayu Fang,while the latter was treated with Gestrinone capsules.Both groups were treated for one course,with 3 months as a course.Side effects and menstruation were observed after one course of treatment,and recurrence rate after medi-cation withdrawal,dysmenorrhea,gestation and level of CA125 were observed 6 months after medication withdrawal.RE-SULTS There was no significant difference between two groups in recurrence rate and changes in level of CA125 (P >0.05). While significant differences could be found in two groups when it comes to dysmenorrhea,postoperative gestation rate and side effects related to medication(P <0.05).And Chinese material medica group were much better than western medication group. When it comes to menstruation on medication,there was significant difference between two groups (P <0.05~0.01).Com-pared to western medication group,Chinese material medica did not affect menstruation of cases in Chinese materia medica group.CONCLUSION Yiqi Huayu Fang has similar effects in decreasing recurrence rate and level of CA125 to Gestrinone capsules.And the former is much better in increasing chances of gestation,decreasing rate of dysmenorrhea and dysmenorrhea score than the latter.