CAJ | 학술논문

目的：考察不同浓度积雪草、丁香、辛夷挥发油对盐酸氟西汀的体外经皮渗透作用。方法采用改良 Franz 扩散池，以大鼠离体皮肤为渗透屏障，以氮酮为阳性对照，含30％乙醇的盐酸氟西汀溶液为阴性对照，考察不同体积分数的积雪草、丁香、辛夷挥发油对盐酸氟西汀的经皮渗透影响。通过高效液相色谱法测定药物浓度，计算盐酸氟西汀透皮吸收的累积透过量、透过速率和增渗倍数。结果不同体积分数的挥发油中，以10％积雪草挥发油、3％丁香挥发油、5％辛夷挥发油经皮渗透速率最大，渗透速率分别为74．94、207．55、152．81μg·cm－2·h－1／2。结论10％积雪草挥发油、3％丁香挥发油、5％辛夷挥发油对盐酸氟西汀经皮吸收具有显著的促进作用。
목적：고찰불동농도적설초、정향、신이휘발유대염산불서정적체외경피삼투작용。방법채용개량 Franz 확산지，이대서리체피부위삼투병장，이담동위양성대조，함30％을순적염산불서정용액위음성대조，고찰불동체적분수적적설초、정향、신이휘발유대염산불서정적경피삼투영향。통과고효액상색보법측정약물농도，계산염산불서정투피흡수적루적투과량、투과속솔화증삼배수。결과불동체적분수적휘발유중，이10％적설초휘발유、3％정향휘발유、5％신이휘발유경피삼투속솔최대，삼투속솔분별위74．94、207．55、152．81μg·cm－2·h－1／2。결론10％적설초휘발유、3％정향휘발유、5％신이휘발유대염산불서정경피흡수구유현저적촉진작용。
ABSTRACT:OBJECTIVE To study the effects of volatile oils,which were extracted from Centella asiatica,Flos caryophylli, Fols Magnolia,on the transdermal absorption of fluoxetine hydrochloride in vitro .METHODS Using modified Franz diffusion cell and excised male rat skin as transdermal barrier,the effect of volatile oils on permeation degree of fluoxetine hydrochloride from different concentration was compared with 3% azone and negative control group without penetration.The concentration of fluoxetine hydrochloride was determined by HPLC.Accumulative velocity constant and enhancing rate of fluoxetine hydrochlo-ride were calculated.RESULTS The penetration rates (J) of 10% volatile oil in Centella asiatica,3% volatile oil in Flos caryophylli,and 5% volatile oil in Fols Magnolia were 74.94,207.55,152.81 μg.cm-2.h-1/2 ,respectively,which were the largest among the different concentration of volatile oils.CONCLUSION The 10% volatile oil of centella asiatica,3% volatile oil in Flos caryophylli,5% volatile oil in Fols Magnolia could enhance penetration of fluoxetine hydrochloride obviously.