药学实践杂志
藥學實踐雜誌
약학실천잡지
THE JOURNAL OF PHARMACEUTICAL PRACTICE
2015年
3期
217-220
,共4页
韦平艳%苑旺%杨峰%崔黎丽
韋平豔%苑旺%楊峰%崔黎麗
위평염%원왕%양봉%최려려
驻极体%氟尿嘧啶%凝胶贴剂%透皮吸收
駐極體%氟尿嘧啶%凝膠貼劑%透皮吸收
주겁체%불뇨밀정%응효첩제%투피흡수
electret%fluorouracil%gel patch%transdermal delivery
目的:制备并优化驻极体氟尿嘧啶凝胶贴剂及考察贴剂的相关性质。方法通过预实验筛选黏合剂和保湿剂,采用正交设计优化处方,用补偿法测量驻极体贴剂的电荷储存稳定性,用透皮扩散仪和 HPLC仪研究药物的体外透皮作用。结果贴剂基质的最佳配比为PAAS∶明胶∶PVA∶高岭土∶CMC-Na∶保湿剂=0.2∶0.7∶0.5∶0.7∶0.2∶12;制备的贴剂具有良好的电荷储存稳定性;驻极体和3%氮酮均能有效地促进药物释放,且两者有协同促渗作用。结论按最佳条件制备了质量优良的驻极体氟尿嘧啶凝胶贴剂,该贴剂对皮肤无刺激性,且该贴剂的药物释放行为优于一般的凝胶贴剂。
目的:製備併優化駐極體氟尿嘧啶凝膠貼劑及攷察貼劑的相關性質。方法通過預實驗篩選黏閤劑和保濕劑,採用正交設計優化處方,用補償法測量駐極體貼劑的電荷儲存穩定性,用透皮擴散儀和 HPLC儀研究藥物的體外透皮作用。結果貼劑基質的最佳配比為PAAS∶明膠∶PVA∶高嶺土∶CMC-Na∶保濕劑=0.2∶0.7∶0.5∶0.7∶0.2∶12;製備的貼劑具有良好的電荷儲存穩定性;駐極體和3%氮酮均能有效地促進藥物釋放,且兩者有協同促滲作用。結論按最佳條件製備瞭質量優良的駐極體氟尿嘧啶凝膠貼劑,該貼劑對皮膚無刺激性,且該貼劑的藥物釋放行為優于一般的凝膠貼劑。
목적:제비병우화주겁체불뇨밀정응효첩제급고찰첩제적상관성질。방법통과예실험사선점합제화보습제,채용정교설계우화처방,용보상법측량주겁체첩제적전하저존은정성,용투피확산의화 HPLC의연구약물적체외투피작용。결과첩제기질적최가배비위PAAS∶명효∶PVA∶고령토∶CMC-Na∶보습제=0.2∶0.7∶0.5∶0.7∶0.2∶12;제비적첩제구유량호적전하저존은정성;주겁체화3%담동균능유효지촉진약물석방,차량자유협동촉삼작용。결론안최가조건제비료질량우량적주겁체불뇨밀정응효첩제,해첩제대피부무자격성,차해첩제적약물석방행위우우일반적응효첩제。
Objective To study and optimize the preparation process and abserve the related properties of electret flu-orouracil gel patch .Methods the adhesives and moistening agents were screened by preliminary experiment .The optimal matrix proportion in the blank gel patch was obtained with orthogonal design .The charge storage stability of the patch was studied by compensation method .The transdermal behaviors of the patch were evaluated by modified diffusion cell method and HPLC .Results The optimal matrix proportions of PAAS ∶ gelatin ∶ PVA ∶ Kaolin ∶ CMC-Na ∶ moistening agents were 0 .2∶0 .7∶0 .5∶0 .7∶0 .2∶12 .The patch had a good charge storage stability .All the electrets and 3% azone could enhance the cumulative penetration amount of drug and they had synergistic enhancing effect .Conclusion The qualified electret fluorouracil gel patch was prepared under the optimal process ,which had no skin irritation and the behavior of transdermal de-livery was better than that of the traditional gel patch .