CAJ | 학술논문

目的：探讨柴龙解郁丹治疗广泛性焦虑症（肝郁气结证）的临床疗效和安全性。方法选择诊断为广泛性焦虑症（肝郁气结证）患者60例，采用随机双盲安慰剂对照，疗程6周，治疗组给予柴胡解郁丹口服，每次6 g，每日3次。观察 HAMA、自拟中医症状量表、副反应量表（TESS）变化。结果对 HAMA 量表评分、中医症状评分治疗组在2周、4周、6周末均有显著作用，呈递进效应（P ＜0．01），且优于对照组（P ＜0．01）；HAMA 治疗组总有效率93．10％，优于对照组32．26％（P ＜0．01）；自拟中医症状量表治疗组总有效率93．10％，优于对照组29．03％（P ＜0．01）；治疗组中医症状量表各项评分较治疗前差异均有显著性（P ＜0．01），对照组仅在急躁易怒与治疗前比较差异有统计学意义（P ＜0．05）。组间比较，急躁易怒、喜太息、心悸、头昏差异有显著性（P ＜0．01），TESS 评分差异无统计学意义（P ＞0．05）。结论柴龙解郁丹对广泛性焦虑症（肝郁气结证）起效快、安全有效、副反应低、依从性高。
목적：탐토시룡해욱단치료엄범성초필증（간욱기결증）적림상료효화안전성。방법선택진단위엄범성초필증（간욱기결증）환자60례，채용수궤쌍맹안위제대조，료정6주，치료조급여시호해욱단구복，매차6 g，매일3차。관찰 HAMA、자의중의증상량표、부반응량표（TESS）변화。결과대 HAMA 량표평분、중의증상평분치료조재2주、4주、6주말균유현저작용，정체진효응（P ＜0．01），차우우대조조（P ＜0．01）；HAMA 치료조총유효솔93．10％，우우대조조32．26％（P ＜0．01）；자의중의증상량표치료조총유효솔93．10％，우우대조조29．03％（P ＜0．01）；치료조중의증상량표각항평분교치료전차이균유현저성（P ＜0．01），대조조부재급조역노여치료전비교차이유통계학의의（P ＜0．05）。조간비교，급조역노、희태식、심계、두혼차이유현저성（P ＜0．01），TESS 평분차이무통계학의의（P ＞0．05）。결론시룡해욱단대엄범성초필증（간욱기결증）기효쾌、안전유효、부반응저、의종성고。
ABSTRACT:OBJECTIVE To explore the clinical efficacy and safety of Chailong Jieyu pill in treating generalized anxiety dis-order(Stagnation of liver qi syndrome).METHODS A six-week randomized,double-blind,placebo-controlled study was con-ducted on 60 patients with the diagnosis of generalized anxiety disorder(Stagnation of liver qi syndrome).The treatment group took Chailong Jieyu pill orally,every 6g,3 times a day.And then Hamiltonanxietyscale (HAMA),TCMsymptomcustom-scale,Side reaction scale(TESS) were observed.RESULTS The score of HAMA and TCM symptom custom scale in the treatment group had a significant and progressive effect(P <0.01),and were better than that in the control group(P <0.01) after 2 weeks,4 weeks and 6 weeks.For HAMA,the total effective rate of the treatment group was 93.10%,better than that of the control group which was 32.26%(P <0.01).For TCM symptom custom scale,the total effective rate of the treatment group was 93.10%,better than that of the control group which was 29.03% (P <0.01).The every score of TCM symptom custom scale in the treatment group had significant differences after treatment(P <0.01),while score in the control group on-ly had a statistic significance on the symptom of irritability(P <0.05).The comparison between the groups had a significant difference on the symptoms of irritability,sigh,palpitation and dizziness(P <0.01).The score of TESS had no statistic sig-nificance(P >0.05).CONCLUSION Chailong Jieyu Pill is effective and safe and has little side effect,high compliance in treating generalized anxiety disorder(Stagnation of liver qi syndrome).