CAJ | 학술논문

目的：观察健脾养正消癥方对晚期胃癌生存期和生活质量的干预作用。方法共纳入232例患者，随机分为2组，试验组为健脾养正消癥方联合化疗组，对照组为化疗组，观察从入组到死亡的时间，比较2组的生存期、临床症状积分和生活质量评分。结果试验组生存期明显长于对照组，平均天数为（327．27±15．33）d，对照组平均天数为（257．92±16．56）d，2组比较差别有统计学意义（P ＜0．01）。通过生活质量 QLQ-C30量表分析，试验组能明显改善患者的情绪功能、角色功能、疼痛、恶心呕吐、疲乏和食欲丧失等症状和总体健康状况，2组比较差异有统计学意义（P ＜0．05）。通过对中医症状积分的比较，发现试验组能改善患者的胃痛、纳少、乏力和嗳气的症状，2组比较差异有统计学意义（P ＜0．05）。结论健脾养正消癥方配合化疗能明显延长晚期胃癌患者的生存期，改善患者的胃痛等症状，提高患者的生活质量。
목적：관찰건비양정소징방대만기위암생존기화생활질량적간예작용。방법공납입232례환자，수궤분위2조，시험조위건비양정소징방연합화료조，대조조위화료조，관찰종입조도사망적시간，비교2조적생존기、림상증상적분화생활질량평분。결과시험조생존기명현장우대조조，평균천수위（327．27±15．33）d，대조조평균천수위（257．92±16．56）d，2조비교차별유통계학의의（P ＜0．01）。통과생활질량 QLQ-C30량표분석，시험조능명현개선환자적정서공능、각색공능、동통、악심구토、피핍화식욕상실등증상화총체건강상황，2조비교차이유통계학의의（P ＜0．05）。통과대중의증상적분적비교，발현시험조능개선환자적위통、납소、핍력화애기적증상，2조비교차이유통계학의의（P ＜0．05）。결론건비양정소징방배합화료능명현연장만기위암환자적생존기，개선환자적위통등증상，제고환자적생활질량。
ABSTRACT:OBJECTIVE To explore the effect of Jianpi Yangzheng Xiaozheng Fang on survival and life quality of cases with late stage gastric cancer.METHODS Two hundred and thirty-two cases were randomly divided into experiment group and control group.The former was given combined treatment of Jianpi Yangzheng Xiaozheng Fang and chemotherapy,while the latter was treated with chemotherapy only.Survival,clinical symptom score and life quality score were compared between two groups.RESULTS Cases in experiment group survived longer than that of control group,with average days of(327±15.33), while the average survival was (257± 16.56) in control group.There was statistical significance between them (P <0.01). Life quality was compared between two groups through QLQ-C30 scale,which showed that such symptoms as mood function, role function,pain,nausea and vomiting,fatigue and poor appetite and general health got better improvement in experiment group.Statistical significance can be found between them(P <0.05).Comparison of symptoms score from perspective of tra-ditional Chinese medicine between both groups also indicated statistical significance(P <0.05),as the improvement of gastric pain,poor appetite,fatigue and got better improvement in experiment group.CONCLUSION Combined treatment of Jianpi Yangzheng Xiaozheng Fang and chemotherapy is effective in prolonging survival,improving gastric pain and life quality for ca-ses with late stage gastric cancer.