检验医学
檢驗醫學
검험의학
LABORATORY MEDICINE
2015年
5期
484-488
,共5页
何文军%黄家平%梁伟东%莫翔%梁少华
何文軍%黃傢平%樑偉東%莫翔%樑少華
하문군%황가평%량위동%막상%량소화
氧化低密度脂蛋白%C 反应蛋白%经皮冠状动脉介入%再狭窄
氧化低密度脂蛋白%C 反應蛋白%經皮冠狀動脈介入%再狹窄
양화저밀도지단백%C 반응단백%경피관상동맥개입%재협착
Oxidized low-density lipoprotein%C reactive protein%Percutaneous coronary intervention%In-stent restenosis
目的:探讨氧化低密度脂蛋白(ox-LDL)、C 反应蛋白(CRP)对经皮冠状动脉介入治疗(PCI)术后支架内再狭窄(ISR)的预测价值。方法选择行 PCI 术并于术后6个月内接受冠状动脉造影复查的患者186例,其中术后发生 ISR (ISR 组)22例,无 ISR 发生(非 ISR 组)164例。检测两组 PCI 术前和术后血清 ox-LDL、CRP水平。结果 ISR 组和非 ISR 组年龄、性别构成、合并症、血脂水平、血管病变情况等一般资料差异均无统计学意义(P >0.05)。 ISR 组 PCI 术后 ox-LDL、CRP 水平明显高于术前(P <0.05),而非 ISR 组 PCI 术前和术后ox-LDL、CRP 水平无明显改变(P >0.05)。 ISR 组术前、术后 ox-LDL 水平均高于非 ISR 组(P <0.05);术前2组CRP 水平差异无统计学意义(P >0.05),术后 ISR 组明显高于非 ISR 组(P <0.05)。相关分析显示 ISR 组、非ISR 组无论是 PCI 术前还是 PCI 术后,ox-LDL 与 CRP 均呈正相关[ISR 组:术前、术后 r 值(P 值)分别为0.392(0.020)、0.431(0.010);非 ISR 组:术前、术后 r 值(P 值)分别为0.382(0.024)、0.526(0.001)];Logistic回归分析显示术后 ox-LDL[优势比(OR)=1.27,95%可信区间(CI):1.05~1.79]和术前 CRP 水平(OR =1.82,95%CI:1.68~2.30)是 ISR 的独立危险因子。结论 PCI 术后 ox-LDL 和术前 CRP 水平升高对预测 ISR 发生有一定的临床价值。
目的:探討氧化低密度脂蛋白(ox-LDL)、C 反應蛋白(CRP)對經皮冠狀動脈介入治療(PCI)術後支架內再狹窄(ISR)的預測價值。方法選擇行 PCI 術併于術後6箇月內接受冠狀動脈造影複查的患者186例,其中術後髮生 ISR (ISR 組)22例,無 ISR 髮生(非 ISR 組)164例。檢測兩組 PCI 術前和術後血清 ox-LDL、CRP水平。結果 ISR 組和非 ISR 組年齡、性彆構成、閤併癥、血脂水平、血管病變情況等一般資料差異均無統計學意義(P >0.05)。 ISR 組 PCI 術後 ox-LDL、CRP 水平明顯高于術前(P <0.05),而非 ISR 組 PCI 術前和術後ox-LDL、CRP 水平無明顯改變(P >0.05)。 ISR 組術前、術後 ox-LDL 水平均高于非 ISR 組(P <0.05);術前2組CRP 水平差異無統計學意義(P >0.05),術後 ISR 組明顯高于非 ISR 組(P <0.05)。相關分析顯示 ISR 組、非ISR 組無論是 PCI 術前還是 PCI 術後,ox-LDL 與 CRP 均呈正相關[ISR 組:術前、術後 r 值(P 值)分彆為0.392(0.020)、0.431(0.010);非 ISR 組:術前、術後 r 值(P 值)分彆為0.382(0.024)、0.526(0.001)];Logistic迴歸分析顯示術後 ox-LDL[優勢比(OR)=1.27,95%可信區間(CI):1.05~1.79]和術前 CRP 水平(OR =1.82,95%CI:1.68~2.30)是 ISR 的獨立危險因子。結論 PCI 術後 ox-LDL 和術前 CRP 水平升高對預測 ISR 髮生有一定的臨床價值。
목적:탐토양화저밀도지단백(ox-LDL)、C 반응단백(CRP)대경피관상동맥개입치료(PCI)술후지가내재협착(ISR)적예측개치。방법선택행 PCI 술병우술후6개월내접수관상동맥조영복사적환자186례,기중술후발생 ISR (ISR 조)22례,무 ISR 발생(비 ISR 조)164례。검측량조 PCI 술전화술후혈청 ox-LDL、CRP수평。결과 ISR 조화비 ISR 조년령、성별구성、합병증、혈지수평、혈관병변정황등일반자료차이균무통계학의의(P >0.05)。 ISR 조 PCI 술후 ox-LDL、CRP 수평명현고우술전(P <0.05),이비 ISR 조 PCI 술전화술후ox-LDL、CRP 수평무명현개변(P >0.05)。 ISR 조술전、술후 ox-LDL 수평균고우비 ISR 조(P <0.05);술전2조CRP 수평차이무통계학의의(P >0.05),술후 ISR 조명현고우비 ISR 조(P <0.05)。상관분석현시 ISR 조、비ISR 조무론시 PCI 술전환시 PCI 술후,ox-LDL 여 CRP 균정정상관[ISR 조:술전、술후 r 치(P 치)분별위0.392(0.020)、0.431(0.010);비 ISR 조:술전、술후 r 치(P 치)분별위0.382(0.024)、0.526(0.001)];Logistic회귀분석현시술후 ox-LDL[우세비(OR)=1.27,95%가신구간(CI):1.05~1.79]화술전 CRP 수평(OR =1.82,95%CI:1.68~2.30)시 ISR 적독립위험인자。결론 PCI 술후 ox-LDL 화술전 CRP 수평승고대예측 ISR 발생유일정적림상개치。
Objective To investigate the predictive significance of oxidized low-density lipoproteins (ox-LDL) and C reactive protein (CRP) for in-stent restenosis (ISR) after percutaneous coronary intervention (PCI). Methods A total of 186 patients who were given PCI and followed up for 6 months were enrolled.Of them, 22 patients had ISR(ISR group), while the other 164 patients had not ISR(no-ISR group).The pre-and post-PCI serum ox-LDL and CRP were detected.Results There was no statistical significance between the 2 groups in terms of age, sex, morbidity, serum lipid and vessel lesion(P >0.05).Serum ox-LDL and CRP increased significantly in ISR group at post-PCI compared with pre-PCI (P <0.05), while there was no significant change in no-ISR group (P >0.05).Serum ox-LDL were also higher in ISR group compared with no-ISR group at pre-and post-PCI (P <0.05).There was no statistical significance for CRP level between the 2 groups at pre-PCI (P >0.05).However, the significant increase of CRP level in ISR group compared with no-ISR group was present at post-PCI (P <0.05).Correlation analysis revealed that there was positive correlation between pre-and post-PCI for serum ox-LDL and CRP in both ISR and no-ISR groups [ISR group: r(P) values of pre-and post-PCI were 0.392 (0.020) and 0.431 (0.010); no-ISR group: r(P) values of pre-and post-PCI were 0.382 (0.024) and 0.526 (0.001)].The Logistic regression analysis showed that post-PCI ox-LDL [odds ratio (OR) =1.27, 95% confidence interval (CI): 1.05-1.79] and pre-PCI CRP (OR =1.82,95%CI:1.68-2.30) were independent risk factors of ISR.Conclusions Post-PCI ox-LDL and pre-PCI CRP have certain significance in the prediction of ISR.