CAJ | 학술논문

目的：观察补肾益气、化痰通络膏联合舒利迭治疗支气管哮喘的效果及对（ INF）－γ、白细胞介素（ IL）－4的影响。方法于立冬前后15 d，将70例符合入组标准的支气管哮喘患者随机分为舒利迭组和联合组。舒利迭组给予舒利迭（50／250）早晚各1吸。联合组给予补肾益气、化痰通络膏早晚各10 mL口服＋舒利迭（50／250）早晚各1吸。2组疗程均为3个月。观察2组治疗前后哮喘证候积分及血清INF－γ、IL－4水平变化情况，统计2组临床疗效及治疗期间不良反应发生情况。结果联合组总有效率高于舒利迭组（P ＜0.05）。治疗后联合组INF－γ水平高于舒利迭组（P＜0．05），IL－4水平低于舒利迭组（P＜0.05）。2组不良反应发生率比较差异无统计学意义。结论补肾益气、化痰通络膏联合舒利迭治疗支气管哮喘有协同作用，可有效缓解患者症状，升高INF－γ水平，降低IL－4水平，值得推广应用。
목적：관찰보신익기、화담통락고연합서리질치료지기관효천적효과급대（ INF）－γ、백세포개소（ IL）－4적영향。방법우입동전후15 d，장70례부합입조표준적지기관효천환자수궤분위서리질조화연합조。서리질조급여서리질（50／250）조만각1흡。연합조급여보신익기、화담통락고조만각10 mL구복＋서리질（50／250）조만각1흡。2조료정균위3개월。관찰2조치료전후효천증후적분급혈청INF－γ、IL－4수평변화정황，통계2조림상료효급치료기간불량반응발생정황。결과연합조총유효솔고우서리질조（P ＜0.05）。치료후연합조INF－γ수평고우서리질조（P＜0．05），IL－4수평저우서리질조（P＜0.05）。2조불량반응발생솔비교차이무통계학의의。결론보신익기、화담통락고연합서리질치료지기관효천유협동작용，가유효완해환자증상，승고INF－γ수평，강저IL－4수평，치득추엄응용。
Objective It is to observe the effects of the paste of reinforcing kidney to tonify Qi , eliminating phlegm to smooth collaterals ( hereafter referred to as the RE Paste ) combined with Seretide on asthma and the effect on the levels of INF-γ,IL-4.Methods Before and after 15 days of the fortnightly periods "Beginning of Winter",70 patients were randomly di-vided into 2 groups:the Seretide group and the combination group .Patients in the Seretide group were received the Seretide (50/250)twice a day,while patients in the combination group were received above paste 10mL twice a day for 3 months.Be-fore and after treatment , the clinical effects of the two groups were observed ,the levels of INF-γ、IL-4 were measured re-spectively and the incidence of untoward effect during the treatments period were compared .Results The total effective rate of the combination group was higher than that of the Seretide group (P<0.05).Compared with the Seretide group, the level of INF-γin the combination group was higher (P<0.05),while the level of IL-4 was lower (P<0.05)after treatment.The incidence of untoward effect was not significant between the two groups (P>0.05).Conclusion RE Paste combined with Seretide was synergetic , it could effectively relieve symptoms of asthma , raise the level of INF-γ, and reduce the level of IL-4.This treatment method was worth generalizing and applying .