CAJ | 학술논문

目的：观察益肾止衰颗粒对 CKD3~5期患者的临床疗效。方法：单中心的开放性随机对照研究。入选CKD3~5期患者80例，随机分为试验组和对照组。所有入选的患者均予西医基础治疗，试验组在基础治疗上加用益肾止衰颗粒，对照组在基础治疗上加用尿毒清颗粒，疗程24周，每8周观察治疗后eGFR、Scr、BUN、UA、Alb变化。结果：两组的总体疗效相当，组间比较eGFR、Scr、BUN、UA、Alb在各个随访期均差异无统计学意义（ P>0．05）。两组的eGFR在治疗前后及组间比较都差异无统计学意义（ P>0．05），但益肾止衰颗粒组在治疗期间相对保持稳定，而尿毒清颗粒组呈现下降的趋势。益肾止衰颗粒组的Alb有升高的趋势，在24周后差异有统计学意义（ P<0．05）。结论：益肾止衰颗粒具有一定的延缓慢性肾衰竭进展的作用，其疗效与尿毒清颗粒相当，并且能改善慢性肾衰竭患者的营养不良，在卫生经济学上更具有优势。
목적：관찰익신지쇠과립대 CKD3~5기환자적림상료효。방법：단중심적개방성수궤대조연구。입선CKD3~5기환자80례，수궤분위시험조화대조조。소유입선적환자균여서의기출치료，시험조재기출치료상가용익신지쇠과립，대조조재기출치료상가용뇨독청과립，료정24주，매8주관찰치료후eGFR、Scr、BUN、UA、Alb변화。결과：량조적총체료효상당，조간비교eGFR、Scr、BUN、UA、Alb재각개수방기균차이무통계학의의（ P>0．05）。량조적eGFR재치료전후급조간비교도차이무통계학의의（ P>0．05），단익신지쇠과립조재치료기간상대보지은정，이뇨독청과립조정현하강적추세。익신지쇠과립조적Alb유승고적추세，재24주후차이유통계학의의（ P<0．05）。결론：익신지쇠과립구유일정적연완만성신쇠갈진전적작용，기료효여뇨독청과립상당，병차능개선만성신쇠갈환자적영양불량，재위생경제학상경구유우세。
Objective:To observe the effect of Yishenzhishuai particles on patients of chronic kidney disease( CKD)3~4 stage. Methods:An open randomized controlled single-center study. Total 80 patients of CKD 3~4 stage were randomized divided into test group and control group. All patients were accepted the foundation of Western medicine treatment,the patients in test group were plused with Yishenzhishuai particles,and the patients in control group were plused with Niaoduqing particles. The course of treatment was 24 weeks. Observed the changes of estimate glomerular filtration rate( eGFR),serum creatinine( Scr),blood urea ni-trogen( BUN),Uric acid( UA)and plasma albumin( Alb)every 8 weeks. Results:Both groups had similar overall efficacy,eGFR, Scr,BUN,UA,and Alb were not significant difference between the groups for each follow-up period(P>0. 05). eGFR was no sig-nificant difference between before and after treatment and comparison groups(P>0. 05). But eGFR in test group remained relatively stable during the treatment,while it showed a downward trend in Niaoduqing particles. Alb in test group showers a tend to increase, it has statistically significant after 24 weeks(P<0. 05). Conclusion:Yishenzhishuai particles has the effect of a certain decay delay progression of chronic renal failure,the efficacy was quite with Niaoduqing particles. Yishenzhishuai particles can improve malnutri-tion in patients with chronic renal failure,and has more advantages on health economics.