中国医药
中國醫藥
중국의약
CHINA MEDICINE
2015年
6期
834-837
,共4页
糖尿病%颈动脉斑块%1,25-二羟维生素D3
糖尿病%頸動脈斑塊%1,25-二羥維生素D3
당뇨병%경동맥반괴%1,25-이간유생소D3
Diabetes mellitus%Carotid plaque%1,25-dihydroxyvitamin D3
目的 分析糖尿病患者血清1,25-二羟维生素D3[1,25(OH)2D3]水平与颈动脉斑块形成的相关性.方法 选取2013年9月至2014年2月在滨州医学院附属医院住院的糖尿病患者82例(糖尿病组),根据颈动脉超声结果分为颈动脉斑块组(48例)和无颈动脉斑块组(34例),并选取同期体检健康者40名作为对照组.收集受试者一般资料及相关生化指标,测定血清1,25(0H)2D3水平.结果 糖尿病组血清1,25(0H)2D3水平低于对照组[(12 ±5) μg/L比(22±5)μg/L],且颈动脉斑块组中血清1,25(OH)2D3水平明显低于无颈动脉斑块组[(8.3±1.4)μg/L比(18.0 ±2.8) μg/L] (P ＜0.01).颈动脉粥样硬化斑块形成与年龄、吸烟、体重指数、收缩压、糖化血红蛋白(HbA1 c)、低密度脂蛋白胆固醇(LDL-C)呈正相关(r =0.60、0.16、0.43、0.50、0.45、0.32,P＜0.05或P＜0.01),与血清1,25(OH)2D3水平呈负相关(r=-0.55,P＜0.01).多因素Logistic相关分析显示年龄[OR=1.076,95％置信区间(CI):1.040 ～1.115]、吸烟(OR=3.852,95％ CI:1.821 ～7.905)、体重指数(OR=1.623,95％ CI:1.030 ～1.720)、收缩压(OR=1.295,95％ CI:1.040 ～1.493)、HbA1c (OR=1.054,95％ CI:1.032 ～1.260)、LDL-L (OR=1.642,95％ CI:1.135 ～2.320)是糖尿病颈动脉斑块形成的危险因素(均P＜0.05),1,25(OH)2D3(OR=0.986,95％ CI:0.864 ～0.996)是糖尿病颈动脉斑块形成的保护因素(P＜0.01),并且在校正上述因素后,血清1,25(OH)2D3水平仍与颈动脉斑块形成具有独立相关关系.结论 糖尿病患者中血清1,25(OH)2D3水平降低与颈动脉斑块的形成密切相关.
目的 分析糖尿病患者血清1,25-二羥維生素D3[1,25(OH)2D3]水平與頸動脈斑塊形成的相關性.方法 選取2013年9月至2014年2月在濱州醫學院附屬醫院住院的糖尿病患者82例(糖尿病組),根據頸動脈超聲結果分為頸動脈斑塊組(48例)和無頸動脈斑塊組(34例),併選取同期體檢健康者40名作為對照組.收集受試者一般資料及相關生化指標,測定血清1,25(0H)2D3水平.結果 糖尿病組血清1,25(0H)2D3水平低于對照組[(12 ±5) μg/L比(22±5)μg/L],且頸動脈斑塊組中血清1,25(OH)2D3水平明顯低于無頸動脈斑塊組[(8.3±1.4)μg/L比(18.0 ±2.8) μg/L] (P ＜0.01).頸動脈粥樣硬化斑塊形成與年齡、吸煙、體重指數、收縮壓、糖化血紅蛋白(HbA1 c)、低密度脂蛋白膽固醇(LDL-C)呈正相關(r =0.60、0.16、0.43、0.50、0.45、0.32,P＜0.05或P＜0.01),與血清1,25(OH)2D3水平呈負相關(r=-0.55,P＜0.01).多因素Logistic相關分析顯示年齡[OR=1.076,95％置信區間(CI):1.040 ～1.115]、吸煙(OR=3.852,95％ CI:1.821 ～7.905)、體重指數(OR=1.623,95％ CI:1.030 ～1.720)、收縮壓(OR=1.295,95％ CI:1.040 ～1.493)、HbA1c (OR=1.054,95％ CI:1.032 ～1.260)、LDL-L (OR=1.642,95％ CI:1.135 ～2.320)是糖尿病頸動脈斑塊形成的危險因素(均P＜0.05),1,25(OH)2D3(OR=0.986,95％ CI:0.864 ～0.996)是糖尿病頸動脈斑塊形成的保護因素(P＜0.01),併且在校正上述因素後,血清1,25(OH)2D3水平仍與頸動脈斑塊形成具有獨立相關關繫.結論 糖尿病患者中血清1,25(OH)2D3水平降低與頸動脈斑塊的形成密切相關.
목적 분석당뇨병환자혈청1,25-이간유생소D3[1,25(OH)2D3]수평여경동맥반괴형성적상관성.방법 선취2013년9월지2014년2월재빈주의학원부속의원주원적당뇨병환자82례(당뇨병조),근거경동맥초성결과분위경동맥반괴조(48례)화무경동맥반괴조(34례),병선취동기체검건강자40명작위대조조.수집수시자일반자료급상관생화지표,측정혈청1,25(0H)2D3수평.결과 당뇨병조혈청1,25(0H)2D3수평저우대조조[(12 ±5) μg/L비(22±5)μg/L],차경동맥반괴조중혈청1,25(OH)2D3수평명현저우무경동맥반괴조[(8.3±1.4)μg/L비(18.0 ±2.8) μg/L] (P ＜0.01).경동맥죽양경화반괴형성여년령、흡연、체중지수、수축압、당화혈홍단백(HbA1 c)、저밀도지단백담고순(LDL-C)정정상관(r =0.60、0.16、0.43、0.50、0.45、0.32,P＜0.05혹P＜0.01),여혈청1,25(OH)2D3수평정부상관(r=-0.55,P＜0.01).다인소Logistic상관분석현시년령[OR=1.076,95％치신구간(CI):1.040 ～1.115]、흡연(OR=3.852,95％ CI:1.821 ～7.905)、체중지수(OR=1.623,95％ CI:1.030 ～1.720)、수축압(OR=1.295,95％ CI:1.040 ～1.493)、HbA1c (OR=1.054,95％ CI:1.032 ～1.260)、LDL-L (OR=1.642,95％ CI:1.135 ～2.320)시당뇨병경동맥반괴형성적위험인소(균P＜0.05),1,25(OH)2D3(OR=0.986,95％ CI:0.864 ～0.996)시당뇨병경동맥반괴형성적보호인소(P＜0.01),병차재교정상술인소후,혈청1,25(OH)2D3수평잉여경동맥반괴형성구유독립상관관계.결론 당뇨병환자중혈청1,25(OH)2D3수평강저여경동맥반괴적형성밀절상관.
Objective To investigate the relation between carotid plaque formation and serum 1,25-dihydroxyvitamin D3 in diabetes mellitus patients.Methods A total of 82 diabetes patients (diabetes group) from September 2013 to February 2014 were enrolled and divided into plaque subgroup (48 cases) and non plaque subgroup (34 cases) according to the results of ultrasound;40 healthy people were selected as control group.The general information and related biochemical indicators were collected;the level of serum 1,25 (OH)2 D3 was measured.Results The level of serum 1,25 (OH)2D3 in diabetes group was significantly lower than that in control group [(12 ±5) μg/L vs (22 ±5) μg/L],in plaque subgroup was significantly lower than that in non plaque subgroup [(8.3 ± 1.4) μg/L vs (18.0 ±2.8) μ/L] (P ＜0.01).Pearson correlation analysis showed that carotid plaque formation was positively correlated with age,smoking,body mass index (BMI),systemic blood pressure (SBP),low-density lipoprotein cholesterol (LDL-C) and glycosylated hemoglobin A1c (HbA1c) (r =0.60,0.16,0.43,0.50,0.45,0.32,P ＜0.05 or P ＜0.01);it was negatively correlated with serum 1,25 (OH)2D3 (r =-0.55,P ＜ 0.01).Multivariate logistic regression revealed that the risk factors of carotid plaque formation in diabetes patients included age [OR =1.076,95％ confidence interval(CI):1.040-1.115),smoking (OR =3.852,95％ CI:1.821-7.905),BMI (OR =1.623,95％ CI:1.030-1.720),SBP (OR=1.295,95％CI:1.040-1.493),HbA1c (OR =1.054,95％CI:1.032-1.260) and LDL-C (OR=1.642,95％CI:1.135-2.320) (all P ＜0.05),while 1,25 (OH)2D3 was the protection factor for carotid plaque formation (OR =0.986,5％CI:0.864-0.996,P ＜0.01).After adjusting correction factors,the level of serum 1,25 (OH)2D3 was independently correlated with carotid plaques formation.Conclusion Low level of serum 1,25 (OH)2D3 level is closely related to the formation of carotid plaque in diabetes patients.
