中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2015年
4期
310-314
,共5页
徐治%张志珺%袁勇贵%李磊%汪天宇
徐治%張誌珺%袁勇貴%李磊%汪天宇
서치%장지군%원용귀%리뢰%왕천우
抗抑郁药物%基因%环境%去甲肾上腺素转运体
抗抑鬱藥物%基因%環境%去甲腎上腺素轉運體
항억욱약물%기인%배경%거갑신상선소전운체
Antidepressant drugs%Gene%Environment%Norepinephrine transporter
目的 探讨去甲肾上腺素转运体(NET)基因多态性与抗抑郁剂疗效的相关性,以及基因和环境相互作用对抗抑郁药物疗效的影响.方法 281例符合入组标准的抑郁症患者给予抗抑郁剂治疗,随访6周,采用17项汉密尔顿抑郁量表(HAMD-17)评定抗抑郁疗效,采用Illumina Golden Gate定制芯片测定与抗抑郁药物疗效密切相关的NET基因的3个单核苷酸多态性(SNPs).采用儿童创伤经历量表(CTQ-SF)了解患者早期生活事件,采用生活事件量表(LES)测定患者近1年内生活事件,并用unphased-3.0.13软件包分析基因多态性与抗抑郁剂疗效的关系,SPSS 13.0分析NET的基因多态性与生活应激的相互作用对抗抑郁剂疗效的影响.结果 在研究的男性亚组中发现,NET基因SNP rs2242446的C等位基因频率在无效组显著高于起效组[0.4118,0.2375,x2=7.046,P=0.0079,OR=0.445,95％ CI(0.243～ 0.815)],NET的基因SNPs rs2242446和rs5569构成的单倍型C-G型[x2=5.886,P=0.0153,OR=0.457,95％ CI(0.198～1.054)]以及rs2242446、rs1532701和rs5569构成的单倍型C-G-G型[x2=5.360,P=0.0206,OR=0.530,95％CI (0.202～1.386)]的频率在无效组显著高于起效组.早期生活事件与NET基因SNP rs5569的AA基因型相互作用引起更差抗抑郁疗效[β=-2.727,SE=1.195,P=0.023,OR=0.065,95％ CI(0.006 ～0.681)].结论 不仅NET的基因多态性会影响抗抑郁剂疗效,而且NET的基因多态性与儿童创伤事件相互作用引起更差的疗效.
目的 探討去甲腎上腺素轉運體(NET)基因多態性與抗抑鬱劑療效的相關性,以及基因和環境相互作用對抗抑鬱藥物療效的影響.方法 281例符閤入組標準的抑鬱癥患者給予抗抑鬱劑治療,隨訪6週,採用17項漢密爾頓抑鬱量錶(HAMD-17)評定抗抑鬱療效,採用Illumina Golden Gate定製芯片測定與抗抑鬱藥物療效密切相關的NET基因的3箇單覈苷痠多態性(SNPs).採用兒童創傷經歷量錶(CTQ-SF)瞭解患者早期生活事件,採用生活事件量錶(LES)測定患者近1年內生活事件,併用unphased-3.0.13軟件包分析基因多態性與抗抑鬱劑療效的關繫,SPSS 13.0分析NET的基因多態性與生活應激的相互作用對抗抑鬱劑療效的影響.結果 在研究的男性亞組中髮現,NET基因SNP rs2242446的C等位基因頻率在無效組顯著高于起效組[0.4118,0.2375,x2=7.046,P=0.0079,OR=0.445,95％ CI(0.243～ 0.815)],NET的基因SNPs rs2242446和rs5569構成的單倍型C-G型[x2=5.886,P=0.0153,OR=0.457,95％ CI(0.198～1.054)]以及rs2242446、rs1532701和rs5569構成的單倍型C-G-G型[x2=5.360,P=0.0206,OR=0.530,95％CI (0.202～1.386)]的頻率在無效組顯著高于起效組.早期生活事件與NET基因SNP rs5569的AA基因型相互作用引起更差抗抑鬱療效[β=-2.727,SE=1.195,P=0.023,OR=0.065,95％ CI(0.006 ～0.681)].結論 不僅NET的基因多態性會影響抗抑鬱劑療效,而且NET的基因多態性與兒童創傷事件相互作用引起更差的療效.
목적 탐토거갑신상선소전운체(NET)기인다태성여항억욱제료효적상관성,이급기인화배경상호작용대항억욱약물료효적영향.방법 281례부합입조표준적억욱증환자급여항억욱제치료,수방6주,채용17항한밀이돈억욱량표(HAMD-17)평정항억욱료효,채용Illumina Golden Gate정제심편측정여항억욱약물료효밀절상관적NET기인적3개단핵감산다태성(SNPs).채용인동창상경력량표(CTQ-SF)료해환자조기생활사건,채용생활사건량표(LES)측정환자근1년내생활사건,병용unphased-3.0.13연건포분석기인다태성여항억욱제료효적관계,SPSS 13.0분석NET적기인다태성여생활응격적상호작용대항억욱제료효적영향.결과 재연구적남성아조중발현,NET기인SNP rs2242446적C등위기인빈솔재무효조현저고우기효조[0.4118,0.2375,x2=7.046,P=0.0079,OR=0.445,95％ CI(0.243～ 0.815)],NET적기인SNPs rs2242446화rs5569구성적단배형C-G형[x2=5.886,P=0.0153,OR=0.457,95％ CI(0.198～1.054)]이급rs2242446、rs1532701화rs5569구성적단배형C-G-G형[x2=5.360,P=0.0206,OR=0.530,95％CI (0.202～1.386)]적빈솔재무효조현저고우기효조.조기생활사건여NET기인SNP rs5569적AA기인형상호작용인기경차항억욱료효[β=-2.727,SE=1.195,P=0.023,OR=0.065,95％ CI(0.006 ～0.681)].결론 불부NET적기인다태성회영향항억욱제료효,이차NET적기인다태성여인동창상사건상호작용인기경차적료효.
Objective To determine how genetic polymorphisms in norepinephrine transporter (NET) gene influence the response of antidepressant treatment and how they interact with childhood trauma and recent life stress in a Chinese depressive patients.Methods 281 Chinese Han depressive patients received single antidepressant drugs for 6 weeks.Hamilton Depression Scale-17 (HAMD-17),the Childhood Trauma Questionnaire short term (CTQ-SF) and the Life Events Scale (LES) were used to evaluate severity of depressive symptoms and the occurrence of stressful life events respectively.Three single nucleotide polymorphisms (SNPs) in norepinephrine transporter were genotyped.Associations of single locus and haplotypes with antidepressant treatment response were analyzed using UNPHASED 3.0.13.The interaction of gene and life stress was analyzed by SPSS13.0 software.Results One NET SNP rs2242446 was significantly associated with antidepressant response in this Chinese male sample(0.4118vs0.2375,x2=7.046,P=0.0079,OR=0.445,95％ CI (0.243-0.815)),as was the haplotype CG(rs2242446 and rs5569;x2 =5.886,P=0.0153,OR=0.457,95％ CI (0.198-1.054)) and another haplotype CG-G(rs2242446,rs1532701 and rs5569;x2=5.360,P=0.0206,OR=0.530,95％ CI (0.202-1.386)) of NET in male samples.The NET SNPs rs5569 demonstrated interaction with childhood trauma to influence antidepressant response(β=-2.727,SE =1.195,P=0.023,OR=0.065,95％ CI (0.006-0.681)).Conclusion Antidepressant drug response was influenced by not only NET genetic polymorphisms in norepinephrine transporter gene but also interaction between the NET genetic polymorphisms and early life stress.
