中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2015年
4期
323-325
,共3页
刘莹%秦琴%赵永萍%仇玉莹%张静%贾琼%程世翔%张赛%李洁
劉瑩%秦琴%趙永萍%仇玉瑩%張靜%賈瓊%程世翔%張賽%李潔
류형%진금%조영평%구옥형%장정%가경%정세상%장새%리길
重性抑郁障碍%FK506结合蛋白5%基因多态性
重性抑鬱障礙%FK506結閤蛋白5%基因多態性
중성억욱장애%FK506결합단백5%기인다태성
Major depressive disorder%FK506-binding proteins 5%Gene polymorphism
目的 探讨FK506结合蛋白5(FK506-binding proteins 5,FKBP5)基因rs1360780多态性与中国汉族人群重性抑郁障碍(major depressive disorder,MDD)之间的关联.方法 以250例MDD患者及300例健康对照作为研究对象,应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)对FKBP5基因rs 1360780进行分型,比较研究组和对照组之间基因型和等位基因频率分布差异.并采用t检验、Hardy-Weinberg平衡检验及x2检验进行统计学分析.结果 (1)病例组FKBP5 rs1360780位点基因分布(CC、CT、TT基因型频率分别为59.6％、36.0％、4.4％,C、T等位基因频率分别为78.2％和21.8％)与对照组(CC、CT、TT基因型频率分别为59.0％、36.3％、4.7％,C、T等位基因频率分别为77.2％和22.8％)相比,均差异无统计学意义(P=0.983;P=0.682);(2)在男性中,病例组FKBP5 rs1360780位点基因分布(CC、CT、TT基因型频率分别为60.3％、33.8％、5.9％,C、T等位基因频率分别为77.2％和22.8％)与对照组(CC、CT、TT基因型频率分别为78.6％、19.0％、2.4％,C、T等位基因频率分别为88.1％和11.9％)相比,均差异有统计学意义(P=0.046;P=0.012),男性中携带T等位基因的人群患MDD的危险度是携带C等位基因的2.185倍(OR=2.185,95％ CI=1.181～4.042).(3) FKBP5基因rs 1360780位点多态性可能与MDD患者的HAMD总分,迟滞、睡眠、Maier、焦虑/躯体化以及核心因子分均无显著关联(P＞0.05).结论 FKBP5基因rs1360780位点多态性可能与中国男性汉族人群MDD发病相关,且携带T可能增加男性患MDD的危险性.
目的 探討FK506結閤蛋白5(FK506-binding proteins 5,FKBP5)基因rs1360780多態性與中國漢族人群重性抑鬱障礙(major depressive disorder,MDD)之間的關聯.方法 以250例MDD患者及300例健康對照作為研究對象,應用聚閤酶鏈反應-限製性片段長度多態性(PCR-RFLP)對FKBP5基因rs 1360780進行分型,比較研究組和對照組之間基因型和等位基因頻率分佈差異.併採用t檢驗、Hardy-Weinberg平衡檢驗及x2檢驗進行統計學分析.結果 (1)病例組FKBP5 rs1360780位點基因分佈(CC、CT、TT基因型頻率分彆為59.6％、36.0％、4.4％,C、T等位基因頻率分彆為78.2％和21.8％)與對照組(CC、CT、TT基因型頻率分彆為59.0％、36.3％、4.7％,C、T等位基因頻率分彆為77.2％和22.8％)相比,均差異無統計學意義(P=0.983;P=0.682);(2)在男性中,病例組FKBP5 rs1360780位點基因分佈(CC、CT、TT基因型頻率分彆為60.3％、33.8％、5.9％,C、T等位基因頻率分彆為77.2％和22.8％)與對照組(CC、CT、TT基因型頻率分彆為78.6％、19.0％、2.4％,C、T等位基因頻率分彆為88.1％和11.9％)相比,均差異有統計學意義(P=0.046;P=0.012),男性中攜帶T等位基因的人群患MDD的危險度是攜帶C等位基因的2.185倍(OR=2.185,95％ CI=1.181～4.042).(3) FKBP5基因rs 1360780位點多態性可能與MDD患者的HAMD總分,遲滯、睡眠、Maier、焦慮/軀體化以及覈心因子分均無顯著關聯(P＞0.05).結論 FKBP5基因rs1360780位點多態性可能與中國男性漢族人群MDD髮病相關,且攜帶T可能增加男性患MDD的危險性.
목적 탐토FK506결합단백5(FK506-binding proteins 5,FKBP5)기인rs1360780다태성여중국한족인군중성억욱장애(major depressive disorder,MDD)지간적관련.방법 이250례MDD환자급300례건강대조작위연구대상,응용취합매련반응-한제성편단장도다태성(PCR-RFLP)대FKBP5기인rs 1360780진행분형,비교연구조화대조조지간기인형화등위기인빈솔분포차이.병채용t검험、Hardy-Weinberg평형검험급x2검험진행통계학분석.결과 (1)병례조FKBP5 rs1360780위점기인분포(CC、CT、TT기인형빈솔분별위59.6％、36.0％、4.4％,C、T등위기인빈솔분별위78.2％화21.8％)여대조조(CC、CT、TT기인형빈솔분별위59.0％、36.3％、4.7％,C、T등위기인빈솔분별위77.2％화22.8％)상비,균차이무통계학의의(P=0.983;P=0.682);(2)재남성중,병례조FKBP5 rs1360780위점기인분포(CC、CT、TT기인형빈솔분별위60.3％、33.8％、5.9％,C、T등위기인빈솔분별위77.2％화22.8％)여대조조(CC、CT、TT기인형빈솔분별위78.6％、19.0％、2.4％,C、T등위기인빈솔분별위88.1％화11.9％)상비,균차이유통계학의의(P=0.046;P=0.012),남성중휴대T등위기인적인군환MDD적위험도시휴대C등위기인적2.185배(OR=2.185,95％ CI=1.181～4.042).(3) FKBP5기인rs 1360780위점다태성가능여MDD환자적HAMD총분,지체、수면、Maier、초필/구체화이급핵심인자분균무현저관련(P＞0.05).결론 FKBP5기인rs1360780위점다태성가능여중국남성한족인군MDD발병상관,차휴대T가능증가남성환MDD적위험성.
Objective To explore the association between FKS06-binding proteins 5 (FKBP5) gene (rs1360780) polymorphisms and major depressive disorder (MDD) in Han Chinese.Methods Genotypes and allele frequencies of rs1360780 of FKBP5 gene were examined in 250 patients and 300 healthy controls by the method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).T-test,Hardy-Weinberg equilibrium and chi-square test were used to conduct statistical analysis.Results (1) The FKBP5 genotypes and alleles frequency distribution between MDD patients (CC,CT,TT genotypes:59.6％,36.0％,4.4％.C,T alleles:78.2％,21.8％) and controls (CC,CT,TT genotypes:59.0％,36.3％,4.7％.C,T alleles:77.2％,22.8％) had no significant difference (P=0.983.P=0.682).(2) However,the frequency of FKBP5 genotypes and alleles distribution between MDD patients (CC,CT,TT genotypes:59.6％,36.0％,4.4％.C,T alleles:78.2％,21.8％) and controls (CC,CT,TT genotypes:59.0％,36.3％,4.7％.C,T alleles:77.2％,22.8％) had statistically difference in male subjects (P=0.046.P=0.012) and subjects with T allele have a higher risk compared to those with C allele to develop MDD (OR=2.185,95％ CI =1.181-4.042).(3) The score of HAMD,retard factor,sleep factor,Maier factor,anxiety/somatization factor and core factor in MDD patients with different genotypes had no significant difference (P＞0.05).Conclusion The results suggest that FKBP5 rs1360780 polymorphisms are associated with the onset of MDD in male Han Chinese.T allele is a risk factor of MDD.
