国际生物医学工程杂志
國際生物醫學工程雜誌
국제생물의학공정잡지
INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING
2015年
2期
81-84,后插3-后插4
,共5页
SD大鼠%工作记忆%局部场电位%锋电位%互信息
SD大鼠%工作記憶%跼部場電位%鋒電位%互信息
SD대서%공작기억%국부장전위%봉전위%호신식
Sprague-dawley rats%Working memory%Local field potentials%Spikes%Mutual information
目的 研究大鼠在Y迷宫工作记忆过程中,责任脑区前额叶皮层记录的2类不同模态的神经信号:局部场电位(LFPs)和锋电位(Spikes)的协同编码,为研究工作记忆的神经编码机制提供计算支持.方法 实验数据:4只SD大鼠在Y迷宫工作记忆过程和静息状态下前额叶皮层的多通道LFPs及Spikes数据由天津医科大学神经工程实验室提供;LFPs的数据预处理:对场电位去除工频干扰和基线漂移;Spikes的连续化:选取生理窗口为500ms,窗口移动步长为125 ms,把Spikes通过发放频率的方式转换为连续信号;场电位的时频分析与特征频段的提取:通过短时傅里叶变换,获取能量分布的主要频段,并通过带通滤波提取特征频段信号,从而得到2种不同模态信号的数据对;特征频段的场电位与锋电位的互信息编码:对单通道的LFPs-Spikes数据序列加窗,计算每个滑动窗口内的互信息值,进而得到多通道的互信息值的分布.结果 场电位的时频分布表明工作记忆期间其能量主要集中在θ频段(4～12 Hz);4只大鼠θ频段LFPs与Spikes在10次工作记忆实验中平均值为0.49±0.04、0.39±-0.03、0.41±0.03、0.48±-0.02,显著大于各自静息状态的值,其差异具有统计学意义(P＜0.05).结论 θ频段(4～12 Hz)是工作记忆的特征频段,θ频段的LFPs与Spikes的互信息有效编码了工作记忆事件.
目的 研究大鼠在Y迷宮工作記憶過程中,責任腦區前額葉皮層記錄的2類不同模態的神經信號:跼部場電位(LFPs)和鋒電位(Spikes)的協同編碼,為研究工作記憶的神經編碼機製提供計算支持.方法 實驗數據:4隻SD大鼠在Y迷宮工作記憶過程和靜息狀態下前額葉皮層的多通道LFPs及Spikes數據由天津醫科大學神經工程實驗室提供;LFPs的數據預處理:對場電位去除工頻榦擾和基線漂移;Spikes的連續化:選取生理窗口為500ms,窗口移動步長為125 ms,把Spikes通過髮放頻率的方式轉換為連續信號;場電位的時頻分析與特徵頻段的提取:通過短時傅裏葉變換,穫取能量分佈的主要頻段,併通過帶通濾波提取特徵頻段信號,從而得到2種不同模態信號的數據對;特徵頻段的場電位與鋒電位的互信息編碼:對單通道的LFPs-Spikes數據序列加窗,計算每箇滑動窗口內的互信息值,進而得到多通道的互信息值的分佈.結果 場電位的時頻分佈錶明工作記憶期間其能量主要集中在θ頻段(4～12 Hz);4隻大鼠θ頻段LFPs與Spikes在10次工作記憶實驗中平均值為0.49±0.04、0.39±-0.03、0.41±0.03、0.48±-0.02,顯著大于各自靜息狀態的值,其差異具有統計學意義(P＜0.05).結論 θ頻段(4～12 Hz)是工作記憶的特徵頻段,θ頻段的LFPs與Spikes的互信息有效編碼瞭工作記憶事件.
목적 연구대서재Y미궁공작기억과정중,책임뇌구전액협피층기록적2류불동모태적신경신호:국부장전위(LFPs)화봉전위(Spikes)적협동편마,위연구공작기억적신경편마궤제제공계산지지.방법 실험수거:4지SD대서재Y미궁공작기억과정화정식상태하전액협피층적다통도LFPs급Spikes수거유천진의과대학신경공정실험실제공;LFPs적수거예처리:대장전위거제공빈간우화기선표이;Spikes적련속화:선취생리창구위500ms,창구이동보장위125 ms,파Spikes통과발방빈솔적방식전환위련속신호;장전위적시빈분석여특정빈단적제취:통과단시부리협변환,획취능량분포적주요빈단,병통과대통려파제취특정빈단신호,종이득도2충불동모태신호적수거대;특정빈단적장전위여봉전위적호신식편마:대단통도적LFPs-Spikes수거서렬가창,계산매개활동창구내적호신식치,진이득도다통도적호신식치적분포.결과 장전위적시빈분포표명공작기억기간기능량주요집중재θ빈단(4～12 Hz);4지대서θ빈단LFPs여Spikes재10차공작기억실험중평균치위0.49±0.04、0.39±-0.03、0.41±0.03、0.48±-0.02,현저대우각자정식상태적치,기차이구유통계학의의(P＜0.05).결론 θ빈단(4～12 Hz)시공작기억적특정빈단,θ빈단적LFPs여Spikes적호신식유효편마료공작기억사건.
Objective This paper aimed to investigate the collaborative coding of two different modes of neural signals including local field potentials and spiking activity (multi-unit activity) which recorded in medial prefrontal cortex of sprague-dawley (SD) rats in Y maze working memory (WM) task,to provide computing support for neural coding mechanism of WM.Methods 1.Experiment data was multi-channel neural signals (local field potentials (LFPs)-Spikes) recorded from prefrontal cortex of 4 SD rats during WM process and resting state,provided by the lab of Neuro-engineering,Tianjin Medical University.2.LFPs preprocessing included baseline drift removing and power-line noise eliminating.3.Physiology window width 500 ms,step 125 ms were selected and average rate per channel was calculated to turn the discrete point signal spikes to continuous signal.4.LFPs characteristic frequency band was obtained by using short time Fourier transform and signals of the characteristic frequency band were extracted by band pass filter.5.Mutual information (MI) of LFPs-spikes was computed to get the distribution of multi-channel MI values.Results 1.LFPs distribution demonstrated that the power focused at θ band (4-12 Hz)during the WM tasks.2.The average MI value of θ band LFPs and spikes (4 rats,over 10 trials) were 0.49±0.04,0.39±0.03,0.41±0.03,0.48±0.02,respectively,which were significantly larger than those in the resting state (t test,P＜0.05).Conclusions These findings indicate that θ band LFPs represents behavior correlated to WM and its synergy with spiking activity plays an important role in encoding WM task.
