CAJ | 학술논문

目的探讨5-羟色胺(5-hydroxytryptamine,5-HT)对卒中后抑郁(post stroke depression,PSD)发生、发展的影响.方法在万方数据库、中国知网及PubMed中进行检索,纳入2010～2014年关于5-HT系统与PSD相关性研究的文献.根据文献的纳入、排除标准汇总文献,并进行总结、归纳和分析.结果检索文献258篇,纳入符合标准文献44篇,涉及5-HT水平与PSD关系、5-羟色胺受体(5-hydroxytryptaminereceptor,5-HTR)基因多态性与PSD的关系、5-羟色胺转运体连锁启动区(5-hydroxytryptamine transporterlinked promoter region,5-HTTLPR)基因多态性与PSD的关系、5-HT再摄取抑制剂(SSRIs)对PSD的治疗这四个方面.结论 5-HT水平降低导致PSD的发生,且5-HT水平与PSD的严重程度呈负相关;5-HTR1A、5-HTR2A是PSD发生、发展的相关基因;S等位基因及S/S基因型是PSD发生的易感因素,而L等位基因则是PSD发生的保护因素;SSRIs可通过提高突触间隙5-HT水平,从而改善PSD患者的抑郁症状.在今后的研究中,还需要加大样本量来确认两者关系,以及结合其他因素探讨5-HT与PSD关系.
목적 탐토5-간색알(5-hydroxytryptamine,5-HT)대졸중후억욱(post stroke depression,PSD)발생、발전적영향.방법 재만방수거고、중국지망급PubMed중진행검색,납입2010～2014년관우5-HT계통여PSD상관성연구적문헌.근거문헌적납입、배제표준회총문헌,병진행총결、귀납화분석.결과 검색문헌258편,납입부합표준문헌44편,섭급5-HT수평여PSD관계、5-간색알수체(5-hydroxytryptaminereceptor,5-HTR)기인다태성여PSD적관계、5-간색알전운체련쇄계동구(5-hydroxytryptamine transporterlinked promoter region,5-HTTLPR)기인다태성여PSD적관계、5-HT재섭취억제제(SSRIs)대PSD적치료저사개방면.결론 5-HT수평강저도치PSD적발생,차5-HT수평여PSD적엄중정도정부상관;5-HTR1A、5-HTR2A시PSD발생、발전적상관기인;S등위기인급S/S기인형시PSD발생적역감인소,이L등위기인칙시PSD발생적보호인소;SSRIs가통과제고돌촉간극5-HT수평,종이개선PSD환자적억욱증상.재금후적연구중,환수요가대양본량래학인량자관계,이급결합기타인소탐토5-HT여PSD관계.
Objective To investigate the effect of the 5-hydroxytryptamine (5-HT) on the occurrence,development of post-stroke depression (PSD).Methods The literatures on the relationship between 5-HT and PSD were selected from databases such as Wanfang Data,CNKI and PubMed before in 2010-2014.According to absorption and exclusion criteria of the literature,collect literatures,and summary,induce and analyze on them.Results Search 258 literatures and accept 44 literatures accorded with the criteria,including the relationship between 5-HT and PSD,the relationship between 5-hydroxytryptamine receptor (5-HTR) gene polymorphism and PSD,the relationship between 5-hydroxytryptamine transporter linked promoter region (5-HTTLPR) and PSD,and the treatment of selective serotonin reuptake inhibitors (SSRIs) in PSD.Conclusion Reduced levels of 5-HT lead to the occurrence of PSD,and they had a negative correlation;5-HTR 1 A,5-HTR2A are related genes of PSD;S allele and S/S genotype is susceptible factors of PSD,while the L allele is the protective factors of PSD;SSRIs can increase the level of 5-HT in the synaptic gap so as to improve the depressive symptoms of PSD.In the future,it is necessary to increase the sample size to confirm the relationship between 5-HT and PSD,and combine with other factors to explore the relationship between them.