CAJ | 학술논문

背景缝隙连接蛋白43(connexin43,Cx43)是心肌缝隙连接的主要结构,多种心脏病理过程(如缺血/再灌注等)均可使Cx43重分布至侧膜而发生侧膜化.这种侧膜化使缝隙连接脱耦连,导致折返性心律失常,严重影响心脏的功能.目的旨在从Cx43转运及定位过程来阐述心肌Cx43侧膜化的分子机制.内容 Cx43侧膜化与闰盘处N钙黏蛋白、桥粒、紧密连接蛋白-1(zonulaoccludens-1,ZO-1)等连接蛋白(connexins,Cxs)的解耦连,以及细胞骨架蛋白介导的Cx43重定向转运密切相关;此外,Cx43的磷酸化、乙酰化也参与了侧膜化的过程.从Cxs、细胞骨架蛋白、磷酸化、乙酰化4个方面就Cx43侧膜化的分子机制展开具体讨论.趋向为进一步研究Cx43侧膜化机制及临床治疗折返性心律失常提供相关思路及分子基础.
배경 봉극련접단백43(connexin43,Cx43)시심기봉극련접적주요결구,다충심장병리과정(여결혈/재관주등)균가사Cx43중분포지측막이발생측막화.저충측막화사봉극련접탈우련,도치절반성심률실상,엄중영향심장적공능.목적 지재종Cx43전운급정위과정래천술심기Cx43측막화적분자궤제.내용 Cx43측막화여윤반처N개점단백、교립、긴밀련접단백-1(zonulaoccludens-1,ZO-1)등련접단백(connexins,Cxs)적해우련,이급세포골가단백개도적Cx43중정향전운밀절상관;차외,Cx43적린산화、을선화야삼여료측막화적과정.종Cxs、세포골가단백、린산화、을선화4개방면취Cx43측막화적분자궤제전개구체토론.추향 위진일보연구Cx43측막화궤제급림상치료절반성심률실상제공상관사로급분자기출.
Background Connexin43(Cx43) is the major protein of gap junction in the heart.A series of cardiac pathologic processes,such as heart failure and arrhythmias,facilitate Cx43 redistribution to the lateral membrane of the cardiomyocytes from the intercalated disc.The occurrence of gap junctions uncoupling after Cx43 lateralization can lead to reentrant arrhythmias and cardiac dysfunction.Objective To elaborate the molecular mechanisms of myocardial Cx43 lateralization through the process of Cx43 transportation and location.Content The lateralization of Cx43 was proposed to be closely associated with the loss of coupling with connexins (Cxs),i.e.,N-cadherin,desmosomes,Zonula Occludens-1 (ZO-1),and cytoskeletal proteins-mediated forward trafficking of Cx43.Moreover,phosphorylation or acetylation of Cx43 was also involved in its lateralization.This review focusess on the Cxs,cytoskeletal proteins,phosphorylation,and acetylation of Cx43 to show the probable molecular mechanisms of Cx43 lateralization.Trend To provide new ideas and molecular mechanisms for further research into the mechanisms of Cx43 lateralization and the therapy of reentrant arrhythmias.