中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2015年
5期
491-493
,共3页
心力衰竭%S100蛋白质类%利钠肽,脑
心力衰竭%S100蛋白質類%利鈉肽,腦
심력쇠갈%S100단백질류%리납태,뇌
Heart failure%S100 proteins%Natriuretic peptide,brain
目的 探讨S100B水平与心功能及慢性心力衰竭(心衰)的相关性.方法 选择80例老年心衰患者为心衰组,同时选择同期健康体检者80例为对照组.确定心衰组纽约心脏病协会(NYHA)心功能分级.比较两组S100B、NT-proBNP水平,左心室舒张末内径(LVEDD)和左心室射血分数(LVEF).分析S100B与NT-proBNP、LVEF及NYHA心功能分级水平的相关性.结果 心衰组S100B(91.4±31.9)pg/L较对照组(74.9±26.0)pg/L水平升高(t=1.980,P=0.000).NT-proBNP及LVEDD水平升高,LVEF水平降低,差异有统计学意义(均P＜0.01).S100B水平与NT proBNP呈正相关(r=0.309,P=0.003);与NYHA分级呈正相关(r=0.508,P=0.001);与LVEF呈负相关,差异有统计学意义(r=-0.192,P=0.004).结论 S100B蛋白水平在慢性心衰患者中明显升高,且与患者心功能呈负相关,对于心衰诊断和评估的有提示意义,但仍需更多的循征依据.
目的 探討S100B水平與心功能及慢性心力衰竭(心衰)的相關性.方法 選擇80例老年心衰患者為心衰組,同時選擇同期健康體檢者80例為對照組.確定心衰組紐約心髒病協會(NYHA)心功能分級.比較兩組S100B、NT-proBNP水平,左心室舒張末內徑(LVEDD)和左心室射血分數(LVEF).分析S100B與NT-proBNP、LVEF及NYHA心功能分級水平的相關性.結果 心衰組S100B(91.4±31.9)pg/L較對照組(74.9±26.0)pg/L水平升高(t=1.980,P=0.000).NT-proBNP及LVEDD水平升高,LVEF水平降低,差異有統計學意義(均P＜0.01).S100B水平與NT proBNP呈正相關(r=0.309,P=0.003);與NYHA分級呈正相關(r=0.508,P=0.001);與LVEF呈負相關,差異有統計學意義(r=-0.192,P=0.004).結論 S100B蛋白水平在慢性心衰患者中明顯升高,且與患者心功能呈負相關,對于心衰診斷和評估的有提示意義,但仍需更多的循徵依據.
목적 탐토S100B수평여심공능급만성심력쇠갈(심쇠)적상관성.방법 선택80례노년심쇠환자위심쇠조,동시선택동기건강체검자80례위대조조.학정심쇠조뉴약심장병협회(NYHA)심공능분급.비교량조S100B、NT-proBNP수평,좌심실서장말내경(LVEDD)화좌심실사혈분수(LVEF).분석S100B여NT-proBNP、LVEF급NYHA심공능분급수평적상관성.결과 심쇠조S100B(91.4±31.9)pg/L교대조조(74.9±26.0)pg/L수평승고(t=1.980,P=0.000).NT-proBNP급LVEDD수평승고,LVEF수평강저,차이유통계학의의(균P＜0.01).S100B수평여NT proBNP정정상관(r=0.309,P=0.003);여NYHA분급정정상관(r=0.508,P=0.001);여LVEF정부상관,차이유통계학의의(r=-0.192,P=0.004).결론 S100B단백수평재만성심쇠환자중명현승고,차여환자심공능정부상관,대우심쇠진단화평고적유제시의의,단잉수경다적순정의거.
Objective To investigate the correlation of the S100B level with cardiac function and chronic heart failure.Methods A total of 80 elderly chronic heart failure (CHF) patients who accepted treatments in our hospital from March 2012 to December 2013 were recruited,and 80 subjects undergoing health examinations served as the control group.The New York Heart Association (NYHA) functional classification in the experimental group was determined.Serum levels of S100B and NT-proBNP,left ventricular end diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF) were compared between the groups,and the correlation of the S100B level with NT proBNP,LVEF and the NYHA functional classification were analyzed.Results The serum S100B level was increased in the experimental group as compared with the control group [(91.4 ±31.9) pg/L vs.(74.9±26.0) pg/L,t=1.980,P=0.000].The serum NT-proBNP level was higher,LVEDD was longer,and LVEF was lower in the experimental group than in the control group (all P＜0.01).The serum S100B level was positively correlated with NT-proBNP (r=0.309,P=0.003) and the NYHA functional classification (r=0.508,P=0.001),and negatively correlated with the LVEF (r=-0.192,P=0.004).Conclusions The serum S100B level is increased in patients with CHF and negatively correlated with cardiac function,suggesting that the S100B protein may serve as a valuable tool for the diagnosis and assessment of CHF.However,more studies are needed to provide more evidence.
