中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2015年
5期
506-509
,共4页
李燕巍%潘战宇%岳振松%谢广茹%李玲
李燕巍%潘戰宇%嶽振鬆%謝廣茹%李玲
리연외%반전우%악진송%사엄여%리령
癌,非小细胞肺%C反应蛋白质%中草药
癌,非小細胞肺%C反應蛋白質%中草藥
암,비소세포폐%C반응단백질%중초약
Corcinoma,non-small cell lung%C-reactive protein%Drugs,Chinese herbal
目的 观察肺癌Ⅳ号方配合化疗对兼具“热毒”表现的中晚期老年非小细胞肺癌(NSCLC)患者的临床疗效观察.方法 选取我科2013年4月至2014年10月收治的70岁以上中晚期NSCLC并兼具“热毒”表现的患者77例,随机分为化疗组39例,化疗+中药组38例,脱落13例(对照组5例,中药组8例),两组患者均给予化疗的基础上,观察患者加用中药后卡氏评分、有效率、中医主症,及治疗前、后第1、56天超敏C反应蛋白(hs-CRP)及肿瘤标志物中癌胚抗原(CEA)、烯醇化酶(NSE)、肿瘤相关物质检测(TSGF)的变化.结果 两组患者治疗后治疗有效率分别为20.0％、23.5％,两组比较差异无统计学意义(P＞0.05).但加用中药组卡氏评分、中医主症明显改善,分别为36.7％比26.5％和80.0％比58.8％,组间比较差异皆有统计学意义(x2=2.721、6.731,P＜0.05).hs-CRP、CEA、NSE、TSGF水平在用药前后两组组间比较差异无统计学意义(P＞0.05),但hs CRP水平两组自身比较皆较治疗前降低,中药组降低更加明显分别为51.47％、23.77％,且差异有统计学意义(x2=19.713,P＜0.05).结论 肺癌Ⅳ号方可改善兼具“热毒”症候的老年肺癌患者的主要临床症状,提高其生活质量,且老年肺癌患者的化疗耐受性可.并发现中医“热毒”症候与患者hs-CRP水平具有相关性,推测其可能为该症候的物质基础.
目的 觀察肺癌Ⅳ號方配閤化療對兼具“熱毒”錶現的中晚期老年非小細胞肺癌(NSCLC)患者的臨床療效觀察.方法 選取我科2013年4月至2014年10月收治的70歲以上中晚期NSCLC併兼具“熱毒”錶現的患者77例,隨機分為化療組39例,化療+中藥組38例,脫落13例(對照組5例,中藥組8例),兩組患者均給予化療的基礎上,觀察患者加用中藥後卡氏評分、有效率、中醫主癥,及治療前、後第1、56天超敏C反應蛋白(hs-CRP)及腫瘤標誌物中癌胚抗原(CEA)、烯醇化酶(NSE)、腫瘤相關物質檢測(TSGF)的變化.結果 兩組患者治療後治療有效率分彆為20.0％、23.5％,兩組比較差異無統計學意義(P＞0.05).但加用中藥組卡氏評分、中醫主癥明顯改善,分彆為36.7％比26.5％和80.0％比58.8％,組間比較差異皆有統計學意義(x2=2.721、6.731,P＜0.05).hs-CRP、CEA、NSE、TSGF水平在用藥前後兩組組間比較差異無統計學意義(P＞0.05),但hs CRP水平兩組自身比較皆較治療前降低,中藥組降低更加明顯分彆為51.47％、23.77％,且差異有統計學意義(x2=19.713,P＜0.05).結論 肺癌Ⅳ號方可改善兼具“熱毒”癥候的老年肺癌患者的主要臨床癥狀,提高其生活質量,且老年肺癌患者的化療耐受性可.併髮現中醫“熱毒”癥候與患者hs-CRP水平具有相關性,推測其可能為該癥候的物質基礎.
목적 관찰폐암Ⅳ호방배합화료대겸구“열독”표현적중만기노년비소세포폐암(NSCLC)환자적림상료효관찰.방법 선취아과2013년4월지2014년10월수치적70세이상중만기NSCLC병겸구“열독”표현적환자77례,수궤분위화료조39례,화료+중약조38례,탈락13례(대조조5례,중약조8례),량조환자균급여화료적기출상,관찰환자가용중약후잡씨평분、유효솔、중의주증,급치료전、후제1、56천초민C반응단백(hs-CRP)급종류표지물중암배항원(CEA)、희순화매(NSE)、종류상관물질검측(TSGF)적변화.결과 량조환자치료후치료유효솔분별위20.0％、23.5％,량조비교차이무통계학의의(P＞0.05).단가용중약조잡씨평분、중의주증명현개선,분별위36.7％비26.5％화80.0％비58.8％,조간비교차이개유통계학의의(x2=2.721、6.731,P＜0.05).hs-CRP、CEA、NSE、TSGF수평재용약전후량조조간비교차이무통계학의의(P＞0.05),단hs CRP수평량조자신비교개교치료전강저,중약조강저경가명현분별위51.47％、23.77％,차차이유통계학의의(x2=19.713,P＜0.05).결론 폐암Ⅳ호방가개선겸구“열독”증후적노년폐암환자적주요림상증상,제고기생활질량,차노년폐암환자적화료내수성가.병발현중의“열독”증후여환자hs-CRP수평구유상관성,추측기가능위해증후적물질기출.
Objective To explore the therapeutic effect of lung cancer Ⅳ recipe combined with chemotherapy on treating middle and advanced stages of non-small cell lung cancer (NSCLC) in the elderly.Methods A total of 77 NSCLC patients in middle and advanced stages aged 70 years and over who had heat-toxin syndrome in traditional Chinese medicine (TCM) were selected from Apr.2013 to Oct.2014 in our hospital.Patients were randomly divided into chemotherapy group (n=39) and chemotherapy + herbs group (n=38).Karnofsky assessment scale (KPS),effective rate,symptom and sign in traditional Chinese medicine,changes in the levels of high-sensitivity c-reactive protein (hs-CRP),carcino embryonic antigen (CEA),neuron specific enolase (NSE),tumor special growth factor (TSGF) were observed before and 1 and 56 days after treatment.Results There was no significant difference in effective rate between the two groups (P＞0.05).The KPS and symptom and sign in TCM were improved significantly in chemotherapy + herbs group as compared with chemotherapy group (36.7 ％ vs.26.5 ％,80.0 ％ vs.58.8 ％,respectively (x2 =2.721,6.731,both P＜0.05).There were no significant differences in hs-CRP,NSE,CEA,TSGF levels between two groups before and after treatment (P＞0.05),but hs-CRP level in both groups was decreased after treatment as compared to pre-treatment and the decvease was more obvious in chemotherapy + herbs group (51.47％ vs.23.77％,x2 =19.713,P＜0.05).Conclusions Lung cancer Ⅳ recipe can improve the main clinical symptoms,quality of life and tolerance to chemotherapy in NSCLC patients with heat-toxin manifestation in TCM.There is a correlation between heat-toxin syndrome and hsCRP level in NSCLC patients,which shows that hs-CRP probably is the material basis of the heattoxin syndrome in TCM.
